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[Alitretinoin in chronic hand eczema: summary of clinical trials].

Author: RichardM-A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Alitretinoin, an oral retinoid, is effective in treating severe chronic hand eczema (CHE). Studies show a dose-dependent response, with 53% of patients achieving "clear" or "almost clear" skin after 12 weeks of treatment with 10-40 mg per day. Common side effects include headache, flushing, and mucocutaneous signs, as well as an increase in cholesterol and triglycerides.
Paper Details　
Original Abstract of the Article :
After an open preliminary study, two double-blind placebo-controlled randomized studies have confirmed the value of per os alitretinoin in the management of severe chronic hand eczema (CHE). The first showed dose-dependent efficacy and a response defined as "clear" or "almost clear" by 53% of the pa...See full text at original site
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引用元：
https://doi.org/10.1016/S0151-9638(10)70038-7

データ提供：米国国立医学図書館（NLM）

Alitretinoin: A Camel's Journey Through the Desert of Hand Eczema

The field of dermatology is a vast desert, filled with challenges related to skin health and its complexities. Hand eczema, a common and often debilitating condition, can significantly impact quality of life. This study investigates the effectiveness of alitretinoin, a medication used to treat severe chronic hand eczema (CHE). Researchers conducted several clinical trials to evaluate the efficacy and safety of alitretinoin for CHE. Their findings indicated that alitretinoin demonstrated dose-dependent efficacy in improving CHE, with a significant response rate observed in patients receiving 30 mg per day for 12 weeks. The study also confirmed the overall good tolerability of alitretinoin, with common side effects including headache, flushing, and mucocutaneous changes. The study concluded that alitretinoin can be considered a second-line therapy for adults with CHE that does not respond to other treatments.

A Oasis of Hope for Hand Eczema

This research offers a promising treatment option for individuals struggling with severe chronic hand eczema. The study's findings highlight the effectiveness of alitretinoin in improving CHE symptoms, while also emphasizing the importance of careful monitoring for potential side effects.

A Camel's Guide to Skin Health

This research underscores the importance of seeking appropriate medical care for skin conditions. The study's findings highlight the potential benefits of alitretinoin for severe hand eczema. By understanding the various treatment options available, we can work towards achieving healthier and more comfortable skin.

Dr. Camel's Conclusion

This research provides valuable insights into the treatment of severe chronic hand eczema. The study's findings demonstrate the efficacy and tolerability of alitretinoin, offering a promising option for individuals who have not responded to other treatments. As Dr. Camel, I am always seeking knowledge that can alleviate suffering and improve skin health, and this research provides a beacon of hope for those struggling with hand eczema.

Date :
  1. Date Completed 2011-04-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21185982

DOI: Digital Object Identifier

10.1016/S0151-9638(10)70038-7

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Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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