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Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.

Author: BryantZack E, Candelaria-LyonsMelissa S, JabarkhailMedina, JanserIngo, JanserRomy F J, RomeroBrittni B, SteelantWim F A, Van slambrouckSeverine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ethacrynic acid analogues were synthesized and evaluated for their ability to inhibit the migration of human breast and prostate cancer cells. While some analogues showed no inhibitory effect, a precursor in the synthesis process (II-1) was a potent inhibitor of cancer cell migration.
Paper Details　
Original Abstract of the Article :
A series of ethacrynic acid analogues, lacking the α,β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, Hs578Ts(i)8 as well as of human prostate cancer cells, C4-2B. These cell lines provide a good model sy...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21227691

データ提供：米国国立医学図書館（NLM）

Ethacrynic Acid Analogues: A New Weapon in the Fight Against Cancer

This study explored the inhibitory effects of ethacrynic acid analogues, a class of compounds with potential anticancer properties, on human cancer cells. The study aimed to identify new and effective agents for inhibiting cancer cell migration and invasion, critical processes involved in cancer metastasis.

Ethacrynic Acid Analogues: A Promising New Anticancer Agent

The study found that certain ethacrynic acid analogues effectively inhibited the migration of human breast and prostate cancer cells. It's like discovering a new and potent antidote in the desert of cancer research, offering a promising weapon against this devastating disease.

Combatting Cancer: A Multi-Pronged Approach

This research highlights the importance of exploring different approaches to combatting cancer, focusing on key processes such as cell migration and invasion. It's like building a strategic network of oases across the desert, each one addressing a different aspect of the challenge.

Dr.Camel's Conclusion

This study reminds me of the ongoing quest for new and effective cancer treatments. It's like a camel traversing a vast and challenging desert, seeking out new weapons to fight against this formidable foe. The research offers hope for developing more effective and targeted therapies for treating cancer.
Date :
  1. Date Completed 2011-05-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21227691

DOI: Digital Object Identifier

NIHMS265183

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・Effects of ethacrynic acid
SNS
PICO Info
in preparation
Languages

English

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