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Efficacy and safety of pravastatin in patients with primary hypercholesterolemia. I. A dose-response study.

Author: BrownW V, DobsA S, GoldbergA C, HunninghakeD B, InsullW, KnoppR H, MargolisS, MelliesM J, SchaeferE J, SchonfeldG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Pravastatin, a selective inhibitor of HMG-CoA reductase, effectively reduced LDL cholesterol and total cholesterol in patients with primary hypercholesterolemia. The drug was well-tolerated with only transient episodes of rash and headache.
Paper Details　
Original Abstract of the Article :
This multicenter, double-blind, placebo-controlled, dose-response study was conducted in patients with primary hypercholesterolemia to examine the effects of pravastatin, a selective inhibitor of HMG-CoA reductase, on plasma lipids and lipoproteins. A total of 306 patients on cholesterol-lowering di...See full text at original site
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引用元：
https://doi.org/10.1016/0021-9150(90)90185-l

データ提供：米国国立医学図書館（NLM）

Pravastatin: A Cholesterol-Lowering Oasis

High cholesterol is a common health concern, like a desert sandstorm that can clog up our arteries. This research explores the effects of pravastatin, a drug that helps lower cholesterol levels, in people with high cholesterol.

The researchers conducted a study involving hundreds of patients and found that pravastatin effectively lowered cholesterol levels in a dose-dependent manner. Higher doses resulted in greater reductions in cholesterol. The study also found that pravastatin was well-tolerated, with few side effects.

A Heart-Healthy Approach

This research highlights the benefits of pravastatin for lowering cholesterol levels. It's like creating a calming oasis in the midst of a desert sandstorm, helping to protect our hearts from harm.

A Reminder to Consult a Doctor

It's important to consult with a doctor before starting any new medication, including pravastatin. They can help determine the appropriate dosage and monitor your progress.

Dr.Camel's Conclusion

This research offers a promising tool for managing cholesterol levels, potentially creating a more heart-healthy oasis in the desert of our cardiovascular system. Like a skilled desert guide, it's important to work with your doctor to navigate this journey and find the right path for your health.

Date :
  1. Date Completed 1991-03-13
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

2126437

DOI: Digital Object Identifier

10.1016/0021-9150(90)90185-l

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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