Early treatment after stroke for the prevention of late epileptic seizures: a report on the problems performing a randomised placebo-controlled double-blind trial aimed at anti-epileptogenesis.

Author: AldenkampA P, LodderJ, de KromM C T F M, van RaakE P M, van TuijlJ H

Paper Details 
Original Abstract of the Article :
Epileptic seizures in stroke patients are a common complication and adversely affect neurological outcome. We tried to perform a trial aimed at preventing the development of late poststroke seizures using levetiracetam. Levetiracetam is assumed to have anti-epileptogenic properties and might be suit...See full text at original site
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引用元:
https://doi.org/10.1016/j.seizure.2010.12.012

データ提供:米国国立医学図書館(NLM)

Preventing Late Epileptic Seizures After Stroke: A Desert of Challenges

The aftermath of a stroke, like a vast and unforgiving desert, can present numerous challenges for patients, including the potential for late epileptic seizures. This article, like a camel traversing a challenging terrain, explores the complexities of conducting a clinical trial aimed at preventing late poststroke seizures.

The authors, like determined researchers, set out to design a randomized placebo-controlled double-blind trial to investigate the effectiveness of levetiracetam in preventing late poststroke seizures. However, their efforts, like a camel facing an insurmountable sand dune, were met with significant obstacles, highlighting the inherent challenges of conducting such a trial. The authors discuss the difficulty of recruiting and enrolling a sufficient number of patients, the complexities of blinding participants and researchers, and the potential for confounding factors to influence the trial's outcomes.

Navigating the Challenges: The Quest for Stroke Prevention

This article provides valuable insights into the difficulties of conducting clinical trials in neurological disorders. It underscores the importance of careful planning, meticulous execution, and a commitment to addressing the unique challenges of research in this field. The authors highlight the need for ongoing research and innovative approaches to overcome these hurdles and find effective treatments for late poststroke seizures.

Navigating Stroke Recovery: A Camel's Guide

This article serves as a reminder of the complexities of stroke recovery. It emphasizes the importance of seeking professional guidance and support, participating in rehabilitation programs, and adhering to prescribed medications to optimize recovery and minimize the risk of complications, such as late epileptic seizures.

Dr. Camel's Conclusion

This article highlights the ongoing challenges in the quest for stroke prevention and treatment. It reminds us that even in the face of adversity, researchers strive to find solutions to improve patient outcomes. This study serves as a testament to the dedication and perseverance of those who work tirelessly to navigate the complex terrain of neurological disorders, seeking to create a brighter future for those affected by stroke.

Date :
  1. Date Completed 2011-08-03
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21277231

DOI: Digital Object Identifier

10.1016/j.seizure.2010.12.012

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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