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Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.

Author: CamposAlexandre H, CavalcantiAlexandre B, FernandesJuliano L, MaranhãoRaul C, MartinsHerlon S, NicolauJosé C, PesaroAntonio Eduardo P, SerranoCarlos V, SouzaHeraldo P, de LemosJames A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ezetimibe 10mg/simvastatin 20mg (E10/S20) was equally effective in reducing LDL-C compared to simvastatin 80 mg (S80) in patients with stable coronary artery disease (CAD). However, E10/S20 was more effective than S80 in inhibiting platelet aggregation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In the setting of stable coronary artery disease (CAD), it is not known if the pleiotropic effects of cholesterol reduction differ between combined ezetimibe/simvastatin and high-dose simvastatin alone. OBJECTIVE: We sought to compare the anti-inflammatory and antiplatelet effects of ez...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijcard.2011.01.062

データ提供：米国国立医学図書館（NLM）

A Balancing Act: Exploring the Pleiotropic Effects of Cholesterol-Lowering Medications

Maintaining good cholesterol levels is crucial for heart health, like a camel carefully navigating a treacherous desert landscape. This research investigates the effects of two cholesterol-lowering medications, ezetimibe/simvastatin and simvastatin alone, on heart health.

This research compares the effects of ezetimibe/simvastatin and simvastatin alone on inflammatory markers and platelet aggregation in patients with stable coronary artery disease (CAD). The researchers found that both medications effectively reduced cholesterol levels. However, ezetimibe/simvastatin was more effective at inhibiting platelet aggregation, a key factor in preventing blood clots and heart attacks. This finding highlights the importance of considering the specific effects of different medications on heart health, just as a camel chooses the safest path across a desert.

A New Perspective on Cholesterol Management

The study's results suggest that ezetimibe/simvastatin may be more effective at preventing blood clots than simvastatin alone. This finding has important implications for patients with CAD, as it underscores the need for individualized treatment plans that take into account the specific needs of each patient.

Living with Heart Health: What This Means for You

If you're taking cholesterol-lowering medications, it's important to talk to your doctor about the best options for your individual needs. This research highlights the potential benefits of ezetimibe/simvastatin, but it's important to consult with your doctor to ensure that the medication is right for you.

Dr.Camel's Conclusion

Balancing cholesterol levels is essential for heart health. This study provides valuable insights into the pleiotropic effects of different cholesterol-lowering medications, reminding us that each patient's journey to heart health is unique. It's important to consult with your doctor to find the best treatment path for your individual needs, ensuring a smooth journey across the desert of heart health.

Date :
  1. Date Completed 2013-02-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21334753

DOI: Digital Object Identifier

10.1016/j.ijcard.2011.01.062

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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