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[Response to treatment with oral alitretinoin in patients with chronic hand eczema that is refractory to treatment with potent topical corticosteroids: experience in 15 patients].

Author: Aguayo-LeivaI R, Jaén-OlasoloP, UrrutiaS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Alitretinoin, an endogenous derivative of vitamin A, has shown promising results in treating chronic hand eczema. Its efficacy is attributed to its agonist activity on both retinoic acid receptors and retinoid X receptors, which regulate various cellular processes involved in skin health.
Paper Details　
Original Abstract of the Article :
Alitretinoin (9-cis-retinoic acid) is an endogenous derivative of vitamin A and functions as an agonist of both families of nuclear receptors (retinoic acid receptor-α, -β, -γ; retinoid X receptor-α, -β, -γ). It has been investigated in the treatment of chronic hand eczema in many studies in recent ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ad.2010.10.012

データ提供：米国国立医学図書館（NLM）

Treating Chronic Hand Eczema: Finding an Oasis of Relief

Chronic hand eczema is a persistent desert wind, causing dryness, itching, and discomfort. For many patients, finding relief can be a difficult journey. This study examines the effectiveness of alitretinoin, a derivative of vitamin A, in treating chronic hand eczema that is resistant to potent topical corticosteroids. Alitretinoin is like a hidden oasis, offering a potential source of relief for those who have struggled to find relief from chronic hand eczema.

Alitretinoin's Impact on Chronic Hand Eczema

The study found that alitretinoin was effective in treating chronic hand eczema in many patients who had not responded to other treatments. This is like finding a wellspring of water in the desert, providing a source of relief and rejuvenation. Alitretinoin's mechanism of action involves interacting with nuclear receptors, which regulate gene expression and cellular processes. It's like finding a hidden map that reveals the path to healing.

Living with Eczema

Chronic hand eczema can be a challenging condition, but with proper management, it's possible to live a full and happy life. Maintaining a healthy lifestyle, avoiding triggers, and seeking medical advice when needed are all important steps in managing eczema. Just like a desert dweller needs to be mindful of the environment, those with eczema need to be aware of their triggers and take steps to prevent flare-ups.

Dr.Camel's Conclusion

This research offers hope for individuals struggling with chronic hand eczema. Alitretinoin has shown promise in treating cases that have not responded to traditional therapies. However, it's important to remember that every individual is different, and what works for one person may not work for another. It's crucial to consult with a healthcare provider to determine the best treatment approach for your specific needs. Remember, just as a desert oasis can provide temporary respite, treatment for chronic hand eczema may require ongoing management and support.
Date :
  1. Date Completed 2012-01-16
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21354545

DOI: Digital Object Identifier

10.1016/j.ad.2010.10.012

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Languages

Spanish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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