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A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.

Author: BungayPeter J, CallegariErnesto, FennerKatherine S, KayGary G, KempshallSarah, LaPerleJennifer L, MalhotraBimal, MichelMartin C, WebsterRob

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study discusses the variable association of antimuscarinic agents for overactive bladder (OAB) with central nervous system (CNS) side effects. These side effects are related to the selectivity of muscarinic receptor subtypes and the ability of the agent to cross the blood-brain barrier.
Paper Details　
Original Abstract of the Article :
This study provides antimuscarinic agents for overactive bladder (OAB) display variable association with side effects mediated by the central nervous system (CNS), which may be of particular concern in the elderly. Adverse effects on CNS functioning are related to muscarinic receptor subtype selecti...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162653/

データ提供：米国国立医学図書館（NLM）

Crossing the Brain Barrier: Antimuscarinic Agents for Overactive Bladder

Overactive bladder (OAB) is a common condition, affecting millions worldwide. Antimuscarinic agents, which block the action of acetylcholine on muscarinic receptors, are often used to treat OAB. However, some of these agents can cause side effects related to the central nervous system (CNS), particularly in older adults. This study explores the CNS penetration potential of antimuscarinic agents, investigating how these drugs cross the blood-brain barrier and their potential to cause CNS side effects. The study emphasizes the importance of understanding the pharmacokinetic properties of antimuscarinic agents, particularly their ability to cross the blood-brain barrier, to minimize the risk of CNS side effects.

Unlocking the Brain: Understanding CNS Penetration

The study highlights the role of P-glycoprotein (P-gp), a protein that pumps drugs out of the brain, in limiting the penetration of antimuscarinic agents. It's like a vigilant desert guard, preventing unwanted travelers from entering the oasis. Understanding the specific properties of antimuscarinic agents, including their muscarinic receptor subtype selectivity and P-gp interaction, can help clinicians predict their potential for CNS side effects.

Finding the Right Balance: Choosing the Right Drug for OAB

The study underscores the importance of selecting antimuscarinic agents that have a favorable balance between efficacy and CNS side effects. Choosing the right agent for each patient can help optimize treatment outcomes while minimizing the risk of unwanted effects.

Dr.Camel's Conclusion

This study provides valuable information for clinicians treating OAB, emphasizing the importance of considering the CNS penetration potential of antimuscarinic agents. Understanding these factors can help optimize treatment outcomes and minimize the risk of CNS side effects.

Date :
  1. Date Completed 2012-01-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21392072

DOI: Digital Object Identifier

PMC3162653

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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