Paper Details

  1. Home
  2. Paper Details

The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype.

Author: BenkelfatChawki, CoxSylvia M L, GianoulakisChristina, LeytonMarco, PalmourRoberta M, PihlRobert O, SetiawanElaine

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Naltrexone decreases positive subjective effects of alcohol, particularly in women and subjects with the A118G polymorphism of the mu opioid receptor gene.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Few pharmacological treatments for alcohol dependence are available. Moreover, the best supported treatment, naltrexone hydrochloride, appears to work for only some. METHODS: To investigate potential predictors of these differential responses, 40 social drinkers (20 women) were administ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1530-0277.2011.01446.x

データ提供：米国国立医学図書館（NLM）

Naltrexone's Impact on Alcohol's Stimulant Effects

Alcohol dependence is a significant public health concern, and finding effective treatments remains a challenge. Naltrexone hydrochloride is one of the most promising pharmacological treatments, but its effectiveness varies among individuals. This study investigates potential factors that might predict individual responses to naltrexone.

The research involved a double-blind, crossover study with 40 social drinkers, examining the effects of naltrexone versus placebo on alcohol-induced euphoria and motivation for alcohol consumption. The researchers found that naltrexone decreased ethanol-induced euphoria in two subgroups: women and individuals with a specific polymorphism in the mu opioid receptor gene (OPRM1). However, naltrexone didn't significantly reduce motivation to work for more alcohol.

Naltrexone's Effectiveness Varies by Gender and Genotype

This study highlights the importance of considering individual characteristics when determining treatment strategies for alcohol dependence. The findings suggest that naltrexone may be more effective in reducing alcohol's rewarding effects in certain groups, such as women and individuals with specific genetic variations.

Personalized Treatment Strategies for Alcohol Dependence

This research underscores the need for personalized treatment approaches to alcohol dependence. Understanding individual factors, such as gender and genotype, can help tailor treatment strategies to maximize effectiveness and minimize potential side effects. This approach can potentially improve patient outcomes and reduce the burden of alcohol dependence.

Dr. Camel's Conclusion

Just as the desert wind can shift the sands, individual factors can influence the effectiveness of treatments. This study reveals the nuances of naltrexone's effects on alcohol, demonstrating that personalized medicine can pave the way for more effective and targeted treatment strategies.

Date :
  1. Date Completed 2012-03-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21410481

DOI: Digital Object Identifier

10.1111/j.1530-0277.2011.01446.x

Related Literature

Article Analysis
・Effective treatment of alcohol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.