Paper Details 
Original Abstract of the Article :
BACKGROUND: The UL97 protein kinase of human cytomegalovirus phosphorylates the antiviral drug ganciclovir and is the target of maribavir action. A detailed enzyme kinetic analysis of maribavir on the various enzymatic functions of wild type and ganciclovir resistant forms of UL97 is required. METH...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050433/

データ提供:米国国立医学図書館(NLM)

Maribavir's Effects on Ganciclovir-Resistant Cytomegalovirus Mutants

Cytomegalovirus (CMV), like a persistent desert wind, can cause significant health challenges, particularly in individuals with weakened immune systems. This study investigates the effectiveness of maribavir, an antiviral drug, against ganciclovir-resistant mutants of CMV. The authors meticulously analyzed the enzymatic activity of maribavir against both wild-type and ganciclovir-resistant CMV strains, providing insights into its potential to combat drug resistance. This research, like a desert researcher studying the complex adaptations of desert organisms, delves into the intricate mechanisms of drug resistance.

Maribavir's Potency Against Ganciclovir-Resistant Mutants

The study found that maribavir effectively inhibited the autophosphorylation of both wild-type and ganciclovir-resistant CMV mutants. This research, like a skilled desert navigator overcoming treacherous terrain, demonstrates the potential of maribavir to circumvent drug resistance.

The Importance of Antiviral Research

This research highlights the importance of ongoing research into antiviral therapies, particularly in the face of emerging drug resistance. This study, like a desert oasis providing refuge from the harsh environment, offers hope for patients battling CMV infections.

Dr.Camel's Conclusion

This study, like a camel traversing a challenging desert, underscores the importance of finding solutions to combat drug resistance in viral infections.

Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21429239

DOI: Digital Object Identifier

PMC3050433

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.