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[Combined chemo- and hormone-therapy in advanced ovarian carcinoma--theoretical, experimental foundations and clinical results].

Author: SeveldaP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study aimed to improve the treatment of advanced ovarian cancer by combining chemotherapy and hormone therapy. A new chemotherapy regimen (AP-VC-MTX) was developed, which used a sequence of different chemotherapy drugs to overcome drug resistance. This regimen was found to be as effective as standard chemotherapy but with fewer side effects (lower kidney and gastrointestinal toxicity). The study also investigated the use of medroxyprogesterone acetate (MPA) as hormone therapy, showing that it had anti-cancer effects and fewer side effects. The combination of AP-VC-MTX chemotherapy and MPA was chosen as the standard treatment for advanced ovarian cancer.
Paper Details　
Original Abstract of the Article :
The dissatisfying results achieved in the therapy of ovarian carcinoma with an unchanging low rate (between 10% and 30%) of five-year-survival were the reason for efforts to develop a new treatment scheme combining chemotherapy with hormone therapy for epithelial ovarian carcinoma in FIGO stages III...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2145702

データ提供：米国国立医学図書館（NLM）

Combined Chemo- and Hormone-Therapy for Ovarian Cancer

Ovarian cancer, a challenging disease with a significant impact on women's health, has traditionally been treated with chemotherapy. However, this study explores a novel approach that combines chemotherapy with hormone therapy to enhance treatment outcomes for patients with advanced ovarian carcinoma. The researchers investigated the effectiveness of a multi-drug chemotherapy regimen (AP-VC-MTX) in comparison to standard chemotherapy approaches and explored the role of hormone therapy with medroxyprogesterone acetate (MPA) in combination with chemotherapy. The study found that the AP-VC-MTX regimen was equally effective as standard chemotherapy but with a significantly lower level of side effects. Furthermore, the study demonstrated that MPA, when added to chemotherapy, showed promise in reducing tumor growth. This research suggests that a combined approach, encompassing chemotherapy and hormone therapy, may offer a more effective and less toxic treatment option for advanced ovarian cancer.

A Multi-Pronged Approach to Ovarian Cancer Treatment

This study highlights the potential benefits of combining chemotherapy with hormone therapy to improve treatment outcomes for patients with advanced ovarian cancer. The findings suggest that a multi-pronged approach, incorporating different treatment modalities, may be more effective in targeting cancer cells and reducing the severity of side effects.

Navigating the Complexities of Cancer Treatment

The study underscores the importance of exploring innovative approaches to cancer treatment to overcome the challenges associated with traditional therapies. Just as a camel navigates the complexities of the desert landscape, researchers are navigating the intricacies of cancer treatment in search of better solutions for patients.

Dr.Camel's Conclusion

This study sheds light on the potential of combining chemotherapy and hormone therapy to enhance treatment outcomes for advanced ovarian cancer. The findings suggest that a multi-pronged approach, incorporating different treatment modalities, may offer a more effective and less toxic treatment option. This research underscores the ongoing quest to improve cancer treatments and find innovative ways to combat this challenging disease.
Date :
  1. Date Completed 1990-10-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2145702

DOI: Digital Object Identifier

2145702

SNS
PICO Info
in preparation
Languages

German

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