Nitrate patch prevents steroid-related bone necrosis.

Author: BeckmannRainer, DrescherWolf, HassenpflugJoachim, KadyrovMahmed, KaschRichard, KnobeMatthias, KweiderNisreen, PufeMelanie, PufeThomas, TingartMarkus

Paper Details 
Original Abstract of the Article :
Avascular necrosis of the femoral head is a common complication with disabling effect for young patients after high-dose corticosteroid treatment. We could show that steroids have a vasoconstrictive effect on lateral epiphyseal arteries of the femoral head which could lead to ischemia and subsequent...See full text at original site
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引用元:
https://doi.org/10.1002/jor.21420

データ提供:米国国立医学図書館(NLM)

Nitrate Patch to Prevent Steroid-Related Bone Necrosis

Avascular necrosis of the femoral head is a serious complication that can arise after high-dose corticosteroid treatment, often leaving patients with debilitating pain and limited mobility. This study investigated the potential of a nitrate patch to prevent this complication in a rabbit model. The researchers explored the effects of a nitrate patch on steroid-induced bone necrosis by comparing the incidence of bone necrosis in rabbits treated with methylprednisolone alone to those treated with methylprednisolone plus a nitrate patch.

Nitrate Patch: A Potential Oasis for Bone Health

The study found that the nitrate patch demonstrated a protective effect against steroid-induced bone necrosis in the rabbit model. This finding suggests that nitrate therapy could be a promising strategy for preventing this serious complication, offering a potential lifeline for patients undergoing high-dose corticosteroid treatment.

Protecting Against Bone Necrosis: A Crucial Step

This research highlights the need for innovative strategies to prevent steroid-related bone necrosis. The study suggests that nitrate therapy, as a potential preventative measure, could be a crucial tool for safeguarding the health of individuals undergoing high-dose corticosteroid treatments. It's like uncovering a hidden oasis of hope in the vast desert of medical challenges.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the fight against steroid-related bone necrosis. The findings suggest that nitrate therapy may offer a valuable preventative strategy, paving the way for better outcomes for patients undergoing high-dose corticosteroid treatments. It's a reminder that even in the most challenging medical scenarios, new and promising solutions can emerge, offering a path towards improved patient care and well-being.

Date :
  1. Date Completed 2011-10-10
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

21469180

DOI: Digital Object Identifier

10.1002/jor.21420

Related Literature

SNS
PICO Info
in preparation
Languages

English

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