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Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer.

Author: AngChristine, BryantAndrew, ChanKaren K L, DickinsonHeather O, NaikRaj

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Ultra-radical surgery in women with advanced ovarian cancer and carcinomatosis may result in better survival.  It was unclear whether there were any differences in progression-free survival, QoL and morbidity between the two groups. The cost-effectiveness of this intervention has not been investigated.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Ovarian cancer is the sixth most common cancer among women and the leading cause of death in women with gynaecological malignancies. Opinions differ regarding the role of ultra-radical (extensive) cytoreductive surgery in ovarian cancer treatment.  OBJECTIVES: To evaluate the effectiven...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21491400

データ提供：米国国立医学図書館（NLM）

Ultra-Radical Surgery for Advanced Epithelial Ovarian Cancer: A Critical Evaluation

Epithelial ovarian cancer, a complex and often aggressive disease, presents significant challenges for treatment. This research delves into the effectiveness and safety of ultra-radical (extensive) surgery compared to standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer. The authors searched for studies comparing these surgical approaches, ultimately identifying only one non-randomized study that met their inclusion criteria. While the study suggests that ultra-radical surgery may be associated with improved disease-specific overall survival, especially in patients with carcinomatosis, the evidence is limited due to the study's retrospective nature and high risk of bias. The researchers call for further research, particularly well-designed randomized controlled trials, to definitively assess the benefits and risks of ultra-radical surgery in advanced ovarian cancer.

Navigating the Desert of Uncertainty in Ovarian Cancer Treatment

This research highlights the lack of definitive evidence for ultra-radical surgery in advanced ovarian cancer, leaving us in a desert of uncertainty. The sole non-randomized study included in the review suggests potential benefits, but the quality of the evidence is limited due to its retrospective nature. Like a camel traversing a shifting desert landscape, we need more robust research to guide our decisions and ensure the best possible outcomes for patients with advanced ovarian cancer.

The Importance of Informed Decision-Making

The research emphasizes the need for informed decision-making in the treatment of advanced ovarian cancer. With limited evidence for ultra-radical surgery, patients and their healthcare providers must weigh potential benefits against potential risks. This underscores the importance of open communication, shared decision-making, and careful consideration of individual patient circumstances.

Dr.Camel's Conclusion

The limited evidence regarding ultra-radical surgery for advanced epithelial ovarian cancer underscores the need for further research, particularly well-designed randomized controlled trials, to definitively assess the benefits and risks of this approach.

Date :
  1. Date Completed 2011-04-29
  2. Date Revised 2022-09-06
Further Info :

Pubmed ID

21491400

DOI: Digital Object Identifier

EMS58185

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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