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Effect of dose and a comparison of measures of vaccine take for oral rhesus rotavirus vaccine. The Maryland Clinical Studies Group.

Author: DisneyF A, FrancisA B, GreenJ L, LosonskyG A, MarsocciS M, PichicheroM E, RennelsM B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rhesus rotavirus vaccine serotype 3 (RRV) was effective in inducing an immune response in infants. The 10(5) and 10(4) pfu doses of RRV were the most effective.
Paper Details　
Original Abstract of the Article :
Ninety-six healthy infants ages 2 to 5 months received rhesus rotavirus vaccine serotype 3 (RRV) as a single dose of 10(3), 10(4) or 10(5) plaque-forming units (pfu) in this double-blinded, placebo-controlled study. Half of the infants in each dose group were also randomized to receive either 30 ml ...See full text at original site
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引用元：
https://doi.org/10.1097/00006454-199005000-00007

データ提供：米国国立医学図書館（NLM）

Effect of Dose and Measures of Vaccine Take for Oral Rhesus Rotavirus Vaccine

This double-blinded, placebo-controlled study investigates the efficacy of an oral rhesus rotavirus vaccine (RRV) in infants. The study aimed to determine the optimal dose of RRV and evaluate different measures of vaccine 'take', which refers to the successful induction of an immune response.

Dose-Response Relationship

The study found a dose-response relationship for RRV, with higher doses (104 and 105 plaque-forming units [pfu]) producing significantly higher rates of seroconversion and antibody rises compared to placebo. The lowest dose (103 pfu) was not more immunogenic than placebo.

Factors Affecting Vaccine Response

The study also found that the timing of vaccination (on an empty stomach or with a formula 'buffer') and the infant's pre-vaccination antibody titers could influence the vaccine response. Infants who received a higher RRV dose (105 pfu) showed a greater seroconversion rate regardless of the buffer used.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy and optimal dosing of an oral rhesus rotavirus vaccine. Just as the desert's plant life adapts to varying water availability, infants respond differently to different doses of vaccines. This study highlights the importance of understanding the factors that influence vaccine response, enabling healthcare professionals to optimize vaccination strategies and improve the protection provided to infants.
Date :
  1. Date Completed 1990-07-16
  2. Date Revised 2019-08-18
Further Info :

Pubmed ID

2162027

DOI: Digital Object Identifier

10.1097/00006454-199005000-00007

Related Literature

Article Analysis
・Effects of rotavirus vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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