Effects of the antihistamine diphenhydramine on selected aquatic organisms.

Author: BerningerJason P, BrooksBryan W, ChamblissC Kevin, ConnorsKristin A, DuBowen, EytchesonStephanie A, KolkmeierMark A, ProsserKrista N, ValentiTheodore W

Paper Details 
Original Abstract of the Article :
In recent years pharmaceuticals have been detected in aquatic systems receiving discharges of municipal and industrial effluents. Although diphenhydramine (DPH) has been reported in water, sediment, and fish tissue, an understanding of its impacts on aquatic organisms is lacking. Diphenhydramine has...See full text at original site
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引用元:
https://doi.org/10.1002/etc.590

データ提供:米国国立医学図書館(NLM)

Exploring Diphenhydramine's Impact on Aquatic Life

The world of pharmaceuticals and its effects on the environment is a vast desert, full of hidden dangers and mysteries. This study, conducted by a team of dedicated scientists, dives into the impact of the antihistamine diphenhydramine on our precious aquatic ecosystems. Using standard acute and subchronic methodologies, they analyzed the effects of this drug on various aquatic organisms, including plants, invertebrates, and fish. Their findings shed light on the complex interactions between pharmaceuticals and aquatic life.

Diphenhydramine's Surprising Effects on Aquatic Life

The study revealed that diphenhydramine, commonly found in numerous pharmaceutical formulations, had surprisingly diverse effects on aquatic organisms. While the aquatic plant, Lemna gibba, seemed unaffected by the drug, the fish model, Pimephales promelas, exhibited sensitivity to diphenhydramine, particularly in its feeding behavior. Interestingly, the model aquatic invertebrate, Daphnia magna, proved to be even more sensitive to the drug than the fish model, suggesting potential toxicity through ACh and histamine pathways.

Implications for Environmental Health and Future Research

The results of this study highlight the potential environmental risk associated with diphenhydramine, particularly its impact on aquatic invertebrates. The study emphasizes the need for further investigation into the effects of more potent antihistamines and antihistamine mixtures on aquatic ecosystems. As responsible stewards of our planet, it is crucial to understand the potential consequences of pharmaceuticals on the delicate balance of our natural world.

Dr. Camel's Conclusion

This research is like a camel caravan traversing the vast desert of scientific inquiry, revealing the intricate web of relationships between pharmaceuticals and the environment. Understanding the impact of these drugs on aquatic life is crucial for protecting our precious ecosystems. Just as a camel navigates the desert with careful steps, we must move forward with caution and a deep understanding of the consequences of our actions.

Date :
  1. Date Completed 2011-10-27
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21647947

DOI: Digital Object Identifier

10.1002/etc.590

Related Literature

SNS
PICO Info
in preparation
Languages

English

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