Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation.

Author: CamilleriMichael, Vazquez RoqueMaria

Paper Details 
Original Abstract of the Article :
Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are two functional gastrointestinal disorders that are associated with constipation. CC and IBS-C affect approximately 20% of the general population including the elderly, impairing quality of life. Patients not respond...See full text at original site
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引用元:
https://doi.org/10.1586/egh.11.30

データ提供:米国国立医学図書館(NLM)

Linaclotide: A New Hope for Constipation

Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C), like a heavy load on a camel's back, can significantly impact quality of life. This review explores the potential of linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of CC and IBS-C. Linaclotide, with its unique mechanism of action and localized effect on intestinal epithelial cells, has shown promising results in clinical trials. The review highlights the long-term efficacy and safety of linaclotide, suggesting that it could be a valuable treatment option for patients struggling with CC and IBS-C.

A New Oasis in the Desert of Constipation

This review highlights the potential of linaclotide as a novel treatment for CC and IBS-C. Linaclotide, with its unique mechanism of action and promising clinical trial results, offers a potential solution for patients who have not found relief with traditional treatments. This approach, like discovering a hidden oasis in the desert, could provide much-needed relief and improve quality of life for those suffering from CC and IBS-C.

Living with Constipation: Finding Relief

Constipation, like a sand dune blocking the path, can be a frustrating and uncomfortable experience. This review provides hope for those struggling with CC and IBS-C, highlighting the potential of linaclotide as a safe and effective treatment option. If you are experiencing persistent constipation, it is essential to consult with a doctor to explore all available treatment options and find the solution that is right for you.

Dr. Camel's Conclusion

Linaclotide, a synthetic guanylate cyclase C agonist, holds promise as a treatment for chronic constipation and irritable bowel syndrome with constipation. The drug's unique mechanism of action and positive clinical trial results suggest that it could be a valuable addition to the therapeutic arsenal for these conditions. Remember, like a camel navigating the desert, finding relief from constipation can be a journey, but with the right approach and support, it is possible to reach a destination of comfort and well-being.
Date :
  1. Date Completed 2011-10-07
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

21651347

DOI: Digital Object Identifier

10.1586/egh.11.30

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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