Azacitidine adverse effects in patients with myelodysplastic syndromes.

Author: Franco OsorioR, Martínez-FrancésA, Mercadal VilchezS, San Miguel AmigoL

Paper Details 
Original Abstract of the Article :
Azacitidine is now considered one of the standard-of-care agents for patients with high-risk myelodysplastic syndromes who are not candidates for high-dose chemotherapy. Considering the mechanism of action of the agent, it is critical to maintain adequate dose intensities for prolonged periods of ti...See full text at original site
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引用元:
https://doi.org/10.1007/s12325-011-0024-2

データ提供:米国国立医学図書館(NLM)

Azacitidine: A Promising Treatment for Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS), a group of blood disorders characterized by impaired blood cell production, are often difficult to treat. This study examines the adverse effects of azacitidine, a medication used to treat high-risk MDS. It provides valuable information for healthcare providers on managing the side effects of this drug and maximizing its effectiveness.

Managing the Side Effects of Azacitidine: A Desert Oasis of Care

The researchers identify hematological toxicity as the most common side effect of azacitidine, emphasizing the importance of aggressive prevention and treatment strategies. They highlight the need for growth factor support, blood transfusions, and dose adjustments to manage these side effects. The study also discusses non-hematological side effects, such as gastrointestinal and cutaneous issues, and provides guidance on their management.

Navigating the Desert of MDS: A Multifaceted Approach

This study emphasizes the importance of balancing the benefits and risks of azacitidine treatment. While this drug offers hope for patients with MDS, it is crucial to be aware of its potential side effects and to implement strategies for their prevention and management. A multidisciplinary approach that involves hematologists, oncologists, and other healthcare professionals is essential for ensuring safe and effective treatment.

Dr. Camel's Conclusion

MDS, a complex and often challenging blood disorder, can create a desert landscape for patients. Azacitidine offers a valuable treatment option, but its use requires careful consideration of its potential side effects. By understanding these risks and implementing appropriate management strategies, we can help patients navigate the complexities of MDS and improve their quality of life.

Date :
  1. Date Completed 2011-10-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21688207

DOI: Digital Object Identifier

10.1007/s12325-011-0024-2

SNS
PICO Info
in preparation
Languages

English

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