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Persistence of rabies antibody 5 years after postexposure prophylaxis with vero cell antirabies vaccine and antibody response to a single booster dose.

Author: WangChuanlin, ZhangXiaowei, ZhuZhenggang

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the antibody response to a Vero cell antirabies vaccine, the persistence of antibody for 5 years, and the effect of a booster dose after this interval. The ChengDa rabies vaccine showed high efficacy with limited side effects, ensuring that the exposed patient will be on the safe side of the risk of rabies by the 14th day. A booster dose 5 years later was effective in inducing a good neutralizing antibody response.
Paper Details　
Original Abstract of the Article :
This study was done to investigate the antibody response to a Vero cell antirabies vaccine, the persistence of antibody for 5 years, and the effect of a booster dose after this interval. From August 2005 to February 2011, a total of 195 patients were enrolled into our study due to an animal bite. Th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165231/

データ提供：米国国立医学図書館（NLM）

Rabies Vaccine: A Shield Against a Deadly Threat

This study, published in the *Vaccine*, investigates the persistence of rabies antibodies after postexposure prophylaxis with the Vero cell antirabies vaccine and the antibody response to a single booster dose. Imagine this study as a desert caravan equipped with a protective shield, evaluating the longevity of the shield's effectiveness against the deadly threat of rabies.

Long-Lasting Protection

The study found that the Vero cell antirabies vaccine provided long-lasting protection against rabies, with antibody levels remaining detectable for up to 5 years after the initial vaccination series. This is like a desert traveler carrying a shield that provides sustained protection against the harsh desert environment.

Boosting Immunity for Enhanced Protection

The study also showed that a single booster dose given 5 years after the initial vaccination series effectively boosted antibody levels, providing an extra layer of protection against rabies. This is like reinforcing the traveler's shield, strengthening their defense against the dangers of the desert.

Dr. Camel's Conclusion

This study provides reassuring evidence of the effectiveness of the Vero cell antirabies vaccine, demonstrating its ability to provide long-lasting protection and highlighting the importance of booster doses to maintain immunity. It's like having a reliable shield that can be reinforced for enhanced protection, providing peace of mind in the face of danger.
Date :
  1. Date Completed 2012-01-12
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21752947

DOI: Digital Object Identifier

PMC3165231

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Article Analysis
・Side Effects of rabies vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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