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Behavioral effects of fatty acid amide hydrolase inhibition on morphine withdrawal symptoms.

Author: HasaneinParisa, ShahidiSiamak

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhibition of fatty acid amide hydrolase by URB597 reduced morphine withdrawal symptoms in morphine-addicted rats, suggesting that potentiation of the endocannabinoid system may be a new target strategy for managing morphine addiction.
Paper Details　
Original Abstract of the Article :
Chronic morphine exposure causes tolerance and dependence. The cessation of morphine consumption induces a withdrawal syndrome that may involve cannabinoids and is characterized by undesirable psychological and physical signs. The present study examined whether augmentation of the endocannabinoid sy...See full text at original site
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引用元：
https://doi.org/10.1016/j.brainresbull.2011.06.019

データ提供：米国国立医学図書館（NLM）

Morphine Withdrawal: Harnessing the Power of Endocannabinoids

Morphine withdrawal, the unpleasant side effects that occur when a person stops taking morphine, can be like a sudden desert sandstorm, leaving the body feeling shaky and uncomfortable. This research explores the potential of inhibiting fatty acid amide hydrolase (FAAH), an enzyme that breaks down endocannabinoids, to manage morphine withdrawal symptoms. The authors aim to investigate [主な目的] and determine if FAAH inhibition can alleviate the discomfort associated with morphine withdrawal. They found that [主要な発見], suggesting [研究分野における影響].

FAAH Inhibition: A Hopeful Oasis in the Desert of Addiction

The research suggests that inhibiting FAAH might offer a novel approach to managing morphine withdrawal symptoms. It's like discovering a new plant that can help to soothe the desert traveler's parched throat and reduce the discomfort of the journey. The authors suggest that [研究結果] and emphasize the potential role of endocannabinoids in mediating the effects of morphine and its withdrawal. This research opens new doors for developing more effective and safer treatment strategies for managing opioid addiction.

Navigating the Desert of Addiction: A Collaborative Approach

If you or someone you know is struggling with opioid addiction, it's essential to seek professional help. Just as a desert traveler needs a skilled guide to navigate the treacherous terrain, individuals with addiction need support from healthcare professionals, therapists, and support groups.

Dr.Camel's Conclusion

This research offers a hopeful glimpse into the potential of modulating the endocannabinoid system to manage morphine withdrawal. It's like discovering a hidden oasis that can provide solace and relief from the harsh desert conditions of addiction. The authors highlight the need for further research in this area, but this study offers a promising new avenue for exploring more effective and humane treatment options for those struggling with opioid dependence.
Date :
  1. Date Completed 2012-04-04
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

21763761

DOI: Digital Object Identifier

10.1016/j.brainresbull.2011.06.019

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