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In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery.

Author: SolimanIman Ibrahim, Zaki RizkallaChristianne Mounir, latif AzizRanda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Hydroxyzine HCl, an antihistamine, can cause side effects like dizziness and blurred vision. This study developed a microsponge delivery system for controlled release of hydroxyzine HCl to the skin. This approach aims to reduce side effects by minimizing percutaneous absorption and enabling more targeted delivery to the skin.
Paper Details　
Original Abstract of the Article :
Hydroxyzine HCl is used in oral formulations for the treatment of urticaria and atopic dermatitis. Dizziness, blurred vision, and anticholinergic responses, represent the most common side effects. It has been shown that controlled release of the drug from a delivery system to the skin could reduce t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167254/

データ提供：米国国立医学図書館（NLM）

Hydroxyzine Hydrochloride Microsponges: A New Way to Cross the Desert of Topical Delivery

The journey of [topical drug delivery] is fraught with challenges, seeking to deliver medication directly to the skin while minimizing systemic absorption and side effects. This study explores the use of [hydroxyzine hydrochloride microsponges] as a controlled-release delivery system for topical application. The researchers successfully developed microsponges with high encapsulation efficiency and controlled release properties, demonstrating a potential for reducing the side effects associated with oral hydroxyzine administration.

Microsponges: A Potential Oasis in Topical Drug Delivery

This research offers a promising new route for topical drug delivery. The use of hydroxyzine hydrochloride microsponges holds the potential to minimize systemic absorption and side effects, while enhancing the effectiveness of topical treatment. This innovative approach could be a valuable addition to the landscape of drug delivery.

Topical Drug Delivery: A Camel's Advice

Topical medication can be an effective and often preferred route of administration. This study highlights the potential of microsponges as a novel delivery system. When choosing topical medications, it’s important to discuss options with your doctor and understand the benefits and potential side effects.

Dr.Camel's Conclusion

This study presents a novel approach to topical drug delivery using hydroxyzine hydrochloride microsponges. These microsponges offer the potential to improve the efficacy and safety of topical treatment by controlling drug release and minimizing systemic absorption. Further research is needed to evaluate the long-term benefits and safety of this delivery system.

Date :
  1. Date Completed 2012-03-25
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21800216

DOI: Digital Object Identifier

PMC3167254

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Article Analysis
・Side Effects of hydroxyzine
SNS
PICO Info
in preparation
Languages

English

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