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Comparison of the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro.
Author: ItohFumio, KinoshitaYuichi, KobayashiShinichi, KumaiToshio, MatsumotoNaoki, OhbaKeiichiro, SuzukiSatoshi, TakebaYuko, WatanabeMinoru, YoshidaYutoku
Original Abstract of the Article :
The thienopyridine derivative ticlopidine (TCL) is an inhibitor of adenosine diphosphate-induced platelet aggregation. Combination therapy with a thienopyridine derivative and aspirin is standard after coronary stenting, although more hemorrhagic complications occur with the combination therapy than...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1254/jphs.11048fp
データ提供:米国国立医学図書館(NLM)
Omeprazole and Rabeprazole: Impact on Ticlopidine Metabolism
This research investigates the effects of proton pump inhibitors (PPIs) on the metabolism of ticlopidine, a medication used to prevent blood clots. The study compared the effects of omeprazole and rabeprazole on ticlopidine metabolism in vitro and found that omeprazole was a more potent inhibitor of ticlopidine metabolism. The study suggests that rabeprazole may be a preferable PPI option when ticlopidine is administered concurrently with aspirin.
A Balancing Act of Medications
The study highlights the complex interactions that can occur between different medications. The researchers found that omeprazole had a significant inhibitory effect on ticlopidine metabolism, potentially altering the drug's effectiveness. This research underscores the importance of considering potential drug interactions when prescribing medications and of carefully monitoring patients receiving combination therapies.
Understanding Drug Interactions: A Crucial Step in Patient Care
This research emphasizes the need for healthcare providers to be aware of potential drug interactions and to tailor treatment plans to minimize risks. By understanding how different medications can affect each other, healthcare providers can ensure patient safety and optimize treatment outcomes.
Dr.Camel's Conclusion
This research reminds us that the world of medications is a delicate ecosystem. Just as a desert ecosystem is interconnected, the medications we take can interact with each other in unexpected ways. This research encourages us to approach medication management with awareness and caution, ensuring that our choices promote health and well-being.
Date :
- Date Completed 2012-01-03
- Date Revised 2019-09-11
Further Info :
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