Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban.

Author: AriyawansaJay, BurtonPaul Bryan, MooreKenneth Todd, PlotnikovAlexei Nikolaevich, ThyssenAn, VaccaroNicole

Paper Details 
Original Abstract of the Article :
Many patients with acute coronary syndrome receive chronic dual antiplatelet therapy (acetylsalicylic acid and clopidogrel) for secondary event prophylaxis, and new oral anticoagulants are being investigated as adjunctive therapy in this indication. Gastrointestinal side effects such as bleeding are...See full text at original site
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引用元:
https://doi.org/10.1097/FJC.0b013e31822f6c2b

データ提供:米国国立医学図書館(NLM)

Omeprazole and Rivaroxaban: A Safe Combination for Patients with ACS?

The treatment landscape for [acute coronary syndrome (ACS)] is constantly evolving, with new medications emerging to improve patient outcomes. This study delves into the potential drug interactions between [omeprazole], a commonly used [proton pump inhibitor (PPI)], and [rivaroxaban], a new oral anticoagulant. The authors meticulously investigated the pharmacokinetic and pharmacodynamic interactions between these two medications, seeking to ensure the safety and efficacy of their combined use. Their findings provide valuable insights for clinicians managing patients with [ACS], offering reassurance about the safety of this drug combination.

Navigating the Shifting Sands of Drug Interactions

The authors demonstrate the importance of carefully considering potential drug interactions when treating patients with [ACS]. They highlight the need for a thorough understanding of the pharmacokinetic and pharmacodynamic properties of each medication to ensure safe and effective treatment. This research is like a beacon in the vast desert of drug interactions, guiding clinicians towards a more informed and personalized approach to patient care.

A Safe Oasis in the Desert of ACS Treatment

This study provides reassuring news for patients with [ACS] who require both [PPI] and anticoagulation therapy. The authors demonstrate that [omeprazole] and [rivaroxaban] can be safely administered together, allowing clinicians to address both gastrointestinal side effects and thrombotic risks. This research offers a safe oasis in the desert of [ACS] treatment, providing comfort and hope for patients navigating this challenging journey.

Dr.Camel's Conclusion

This research exemplifies the rigorous scientific approach needed to ensure patient safety in the ever-evolving landscape of [ACS] treatment. By meticulously evaluating potential drug interactions, the authors provide invaluable insights for clinicians, enabling them to make informed decisions about medication combinations for their patients. Let us continue to explore the vast desert of medical knowledge, seeking evidence-based solutions that enhance patient care and improve outcomes.

Date :
  1. Date Completed 2012-04-05
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21822144

DOI: Digital Object Identifier

10.1097/FJC.0b013e31822f6c2b

Related Literature

SNS
PICO Info
in preparation
Languages

English

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