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Positive and negative subjective effects of extended-release oxymorphone versus controlled-release oxycodone in recreational opioid users.

Author: ChakrabortyBijan, McMornStephen, PottsSusan L, SchoedelKerri A, SellersEdward M, ZerbeKathleen

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

At equianalgesic doses, oxymorphone extended release (OM-ER) produced lower positive, negative, and balance subjective effects than oxycodone controlled release (OC-CR). This suggests that analgesic potency may not be reflected in subjective/objective effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the subjective effects of oxymorphone extended release (OM-ER) versus oxycodone controlled release (OC-CR). DESIGN: Randomized, double-blind, crossover study. SETTING: Inpatient unit. SUBJECTS: Healthy, nondependent recreational opioid users. INTERVENTIONS: Single intact or...See full text at original site
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引用元：
https://doi.org/10.5055/jom.2011.0061

データ提供：米国国立医学図書館（NLM）

Oxymorphone vs. Oxycodone: A Tale of Two Opioids

Opioids are powerful medications used for pain relief, but they can also lead to addiction. This research compares the subjective effects of oxymorphone extended release (OM-ER) and oxycodone controlled release (OC-CR) in recreational opioid users. It's like observing two travelers navigating a treacherous desert, seeking the best route to relief, yet wary of the dangers lurking around every corner.

The researchers conducted a randomized, double-blind, crossover study on 35 healthy individuals. They compared the effects of OM-ER and OC-CR at different doses, focusing on positive and negative subjective effects. This research is like comparing the effects of two different types of camel feed – observing how each affects the traveler's journey through the desert.

A Balanced Approach in the Desert of Opioid Use

The researchers found that OM-ER produced lower positive, negative, and overall subjective effects than OC-CR at equivalent doses. This suggests that OM-ER may have a more balanced effect, offering pain relief with fewer intense feelings of euphoria and less potential for abuse. It's like finding a camel with a more gentle and reliable disposition, providing a safer and more stable ride through the desert.

Navigating the Risks and Rewards of Opioids

This research offers valuable insights into the subjective effects of different opioids. It's important to consult with a doctor to discuss the risks and benefits of opioid use. It's like choosing a camel for a long journey through the desert – a decision that requires careful consideration and expert advice.

Dr.Camel's Conclusion

This research provides valuable insights into the subjective effects of oxymorphone and oxycodone. While both medications offer pain relief, OM-ER may have a more balanced effect, potentially reducing the risk of addiction and abuse. It's like finding a more reliable oasis in the desert of opioid use – a potential solution for those seeking pain relief with fewer side effects. Further research is needed to explore the long-term effects of these medications and to develop safer and more effective alternatives.

Date :
  1. Date Completed 2011-08-23
  2. Date Revised 2019-11-12
Further Info :

Pubmed ID

21823549

DOI: Digital Object Identifier

10.5055/jom.2011.0061

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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