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Switch from aprotinin to ε-aminocaproic acid: impact on blood loss, transfusion, and clinical outcome in neonates undergoing cardiac surgery.
Author: GertlerR, LiermannH, MacGuillM, MartinK, MayrN P, SchreiberC, TassaniP, VogtM, WiesnerG
Original Abstract of the Article :
With the withdrawal of aprotinin from worldwide marketing in November 2007, many institutions treating patients at high risk for hyperfibrinolysis had to update their therapeutic protocols. At our institution, the standard was switched from aprotinin to ε-aminocaproic acid (EACA) in all patients und...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1093/bja/aer267
データ提供:米国国立医学図書館(NLM)
Switching Antifibrinolytics in Neonatal Cardiac Surgery
The delicate world of neonatal cardiac surgery, much like navigating a fragile desert ecosystem, requires meticulous attention to detail. This study, like a team of skilled desert guides, explores the impact of switching from aprotinin to ε-aminocaproic acid (EACA) as an antifibrinolytic agent in neonates undergoing cardiac surgery. The researchers, much like desert explorers carefully comparing different routes, compared the effects of these two medications on blood loss, transfusion needs, and overall clinical outcomes. While both medications have been used extensively in the past, this study, like a well-mapped caravan trail, provides a valuable comparison. The findings, like a hidden spring in the desert, revealed that EACA effectively controlled blood loss and reduced transfusion requirements, while demonstrating a comparable clinical outcome to aprotinin. These findings, like a beacon in the desert night, offer valuable insights for managing blood loss in neonatal cardiac surgery.
EACA: A Viable Alternative for Neonatal Cardiac Surgery
This study, like a well-stocked caravan, provides a valuable analysis of the switch from aprotinin to EACA in neonatal cardiac surgery. The researchers found that EACA, like a reliable desert camel, effectively controlled blood loss and reduced transfusion needs, demonstrating its suitability as a viable alternative to aprotinin. This discovery, like a refreshing desert oasis, offers a promising solution for managing blood loss in this delicate surgical setting.
Implications for Health and Lifestyle
The findings of this study, like a map guiding a traveler through a desert, offer valuable information for families facing neonatal cardiac surgery. While further research is needed to confirm these findings and establish optimal dosage, this study suggests that EACA may be a safe and effective alternative to aprotinin for managing blood loss in this setting. It is crucial to consult with a healthcare professional for personalized guidance on managing health during neonatal cardiac surgery.
Dr.Camel's Conclusion
The world of neonatal cardiac surgery, much like a vast and unforgiving desert, requires careful navigation and precise interventions. This study, like a well-equipped caravan, sheds light on the effectiveness of switching from aprotinin to EACA as an antifibrinolytic agent. The findings, like a hidden spring in the desert, reveal that EACA effectively manages blood loss and reduces transfusion needs, offering a promising alternative for treating neonates undergoing cardiac surgery. However, it is crucial to consult with a healthcare professional for personalized guidance on managing your child's health.
Date :
- Date Completed 2012-01-04
- Date Revised 2018-01-26
Further Info :
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