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Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine.

Author: CeliFrancesco S, CostelloRene, CsakoGyorgy, DrinkardBart, KozloskyMerel, LindermanJoyce D, PucinoFrank, SachdevVandana, SkarulisMonica C, SmithSheila, ZemskovaMarina

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

Levothyroxine (L-T(4)) alone may not restore a euthyroid state in all tissues, as observed in rodents. Further research is needed to assess the effectiveness of combination L-T(4)/L-T(3) therapy on thyroid hormone action.
Paper Details　
Original Abstract of the Article :
Levothyroxine (L-T(4)) therapy is based on the assumption that the conversion of T(4) into T(3) provides adequate amounts of active hormone at target tissues. However, in rodents, L-T(4) alone does not restore a euthyroid state in all tissues. Previous combination L-T(4)/liothyronine (L-T(3)) therap...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205882/

データ提供：米国国立医学図書館（NLM）

Liothyronine Therapy: A Comprehensive Look at Metabolic Effects

This research delves into the intricacies of thyroid hormone therapy, exploring the metabolic effects of liothyronine (L-T3) in patients with hypothyroidism. The study compares the metabolic effects of L-T3 to those of levothyroxine (L-T4), the standard treatment for hypothyroidism. Researchers conducted a randomized, double-blind, crossover trial, switching patients between L-T3 and L-T4 therapy. The study found that L-T3 therapy resulted in a more complete restoration of euthyroidism in all tissues, suggesting that L-T3 may be a more effective treatment option for some patients.

Liothyronine: A Potential Alternative for Thyroid Hormone Therapy

The study's findings suggest that L-T3 therapy may be a more effective treatment option for some patients with hypothyroidism, leading to a more complete restoration of euthyroidism. This finding warrants further research to explore the potential benefits of L-T3 therapy in specific patient populations.

Camel's Perspective: Finding the Right Balance in the Desert of Hormones

Imagine a camel carefully navigating a desert landscape, adjusting its pace and water intake to maintain balance. Treating hypothyroidism requires a similar approach, finding the right hormonal balance to restore well-being. This study suggests that L-T3 might be a better option for some patients, offering a more complete restoration of hormonal balance.

Dr.Camel's Conclusion

This research offers valuable insights into the metabolic effects of liothyronine therapy in hypothyroidism. The study's findings suggest that L-T3 may be a more effective treatment option for some patients, leading to a more complete restoration of euthyroidism. Further research is necessary to explore the optimal use of L-T3 therapy in specific patient populations and to better understand its long-term effects on various metabolic parameters.

Date :
  1. Date Completed 2011-12-23
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

21865366

DOI: Digital Object Identifier

PMC3205882

SNS
PICO Info
in preparation
Languages

English

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