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Dose-response relationship of inhaled metaproterenol sulfate in preschool children with mild asthma.

Author: EyzaguirreM, GalantS P, NussbaumE

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Metaproterenol sulfate 5% inhalant solution at a dose of 0.01 mL/kg is effective in treating asthma in preschool children. The drug significantly improved lung function, lasting for up to 3 hours. Side effects were minimal.
Paper Details　
Original Abstract of the Article :
The dose-response relationship of single doses of nebulized metaproterenol sulfate 5% inhalant solution was evaluated by placebo-controlled, parallel-group study of 30 children, aged 3 to 6 years old, with stable asthma. Total respiratory resistance, the primary variable used to assess response, was...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2187175

データ提供：米国国立医学図書館（NLM）

Metaproterenol Sulfate: A Dose-Response Study in Preschoolers

Asthma is a common respiratory condition that can be particularly challenging to manage in preschool children. This study explores the dose-response relationship of inhaled metaproterenol sulfate, a bronchodilator, in preschool children with mild asthma. The researchers conducted a placebo-controlled, parallel-group study to evaluate the effectiveness of different doses of nebulized metaproterenol sulfate in reducing respiratory resistance.

Navigating the Desert of Asthma Treatment: Finding the Right Dose

The researchers found that metaproterenol sulfate at doses of 0.01 and 0.02 mL/kg was effective in reducing respiratory resistance in preschool children with mild asthma. While both doses provided significant bronchodilation, there was no significant difference between the two doses. The effect was sustained for up to three hours with both higher doses.

A Tailored Approach: Individualizing Treatment

The study highlights the importance of finding the optimal dose of medication for each individual patient. The researchers found that a dose of 0.01 mL/kg of metaproterenol sulfate seemed to be optimal for achieving significant and sustained bronchodilation in preschool children with mild asthma.

Dr. Camel's Conclusion

This study provides valuable insights into the dose-response relationship of inhaled metaproterenol sulfate in preschool children with mild asthma. The researchers found that metaproterenol sulfate at doses of 0.01 and 0.02 mL/kg was effective in reducing respiratory resistance. The study highlights the importance of individualizing medication doses to achieve optimal treatment outcomes.
Date :
  1. Date Completed 1990-06-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2187175

DOI: Digital Object Identifier

2187175

Related Literature

Article Analysis
・Side Effects of metaproterenol
SNS
PICO Info
in preparation
Languages

English

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