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A comparison of the effects of ketamine, chloral hydrate and pentobarbital sodium anesthesia on isolated rat hearts and cardiomyocytes.

Author: GaoLiping, JiangXinwei, LiuYing, SunHong, WangGuangming, YanChangdong, ZhangYang

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chloral hydrate was the most suitable anesthetic for studies of isolated hearts and cardiomyocytes in rats. Ketamine and pentobarbital sodium significantly decreased heart rate, left ventricular systolic pressure, and the maximal rate of increase of left ventricular pressure. Pentobarbital sodium also inhibited cell shortening amplitude and reduced the survival rate of cardiomyocytes.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The study was intended to investigate which commonly used anesthetic in intact animals has the least effect on the function of isolated hearts and cardiomyocytes among the anesthetized animals. METHODS: The hearts of male Sprague-Dawley rats were removed after they were anesthetized wit...See full text at original site
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引用元：
https://doi.org/10.2459/JCM.0b013e32834a6697

データ提供：米国国立医学図書館（NLM）

Anesthesia: A Comparative Look at Cardiac Effects

Anesthesia, a critical aspect of medical procedures, often involves the use of various drugs that can impact cardiac function. This study aimed to compare the effects of three commonly used anesthetics – ketamine, chloral hydrate, and pentobarbital sodium – on isolated rat hearts and cardiomyocytes. The researchers meticulously evaluated the impact of these drugs on heart rate, left ventricular systolic pressure, and other cardiac parameters.

Chloral Hydrate: A Heart-Friendly Choice for Cardiac Research

The study revealed that chloral hydrate, among the three anesthetics tested, had the least effect on cardiac function. It did not significantly alter heart rate, left ventricular systolic pressure, or cell shortening amplitude, making it a potentially suitable choice for research involving isolated hearts and cardiomyocytes. This finding highlights the importance of carefully considering the potential cardiac effects of anesthetics when designing research studies.

Navigating the Desert of Anesthesia

This study provides valuable insights into the cardiac effects of commonly used anesthetics. It underscores the importance of selecting anesthetics based on the specific research goals and minimizing any potential adverse effects on cardiac function. Like a skilled traveler navigating a vast desert, researchers need to carefully choose their tools and strategies to ensure the success of their expedition.

Dr.Camel's Conclusion

The desert of anesthesia can be a complex and intricate landscape, with various drugs potentially affecting cardiac function. This study offers a valuable guide for researchers, highlighting the potential benefits of chloral hydrate as a heart-friendly anesthetic for certain studies. It's a reminder that careful consideration of the potential side effects of drugs is crucial in conducting research and ensuring the well-being of participants.
Date :
  1. Date Completed 2012-01-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21873882

DOI: Digital Object Identifier

10.2459/JCM.0b013e32834a6697

Related Literature

Article Analysis
・Effects of chloral hydrate
SNS
PICO Info
in preparation
Languages

English

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