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Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.

Author: ChoeHan, ChoiBok Hee, ChuDaehyun, HyunJin Won, JoSu-Hyun, LeeByung Hoon, LeeSeung Ho

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hydroxyzine blocked hERG channels and prolonged action potential duration in a concentration- and time-dependent manner. This suggests that hydroxyzine may have proarrhythmic effects.
Paper Details　
Original Abstract of the Article :
AIM: To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects. METHODS: hERG channels were expressed in Xenopus oocytes and HEK293 cells, and the effects of hydroxyzine on the channels we...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003299/

データ提供：米国国立医学図書館（NLM）

The Hidden Dunes: Hydroxyzine's Impact on hERG K+ Channels and Cardiac Action Potential Duration

Hydroxyzine, an antihistamine, is commonly used to treat allergies and anxiety. However, this study investigates its potential proarrhythmic effects, exploring its impact on hERG K+ channels, which play a crucial role in cardiac repolarization. The authors demonstrate that hydroxyzine can block hERG channels and prolong action potential duration, potentially increasing the risk of cardiac arrhythmias.

Unveiling the Hidden Dunes: Hydroxyzine's Potential Cardiac Risk

The findings of this study suggest that hydroxyzine, while often considered safe, may pose a risk of proarrhythmia. The authors highlight the importance of understanding the potential cardiac effects of this medication, especially in patients with underlying heart conditions.

Navigating the Desert of Allergy and Anxiety Treatment: A Balancing Act

Managing allergies and anxiety is crucial for well-being, but it is equally important to consider the potential side effects of medications. This research underscores the need for careful evaluation of potential risks and benefits before prescribing hydroxyzine, particularly in individuals with cardiac concerns.

Dr. Camel's Conclusion

This research reveals a hidden dune in the desert of allergy and anxiety treatment. Hydroxyzine, while often considered safe, may pose a risk of proarrhythmia due to its effects on hERG channels. This finding reminds us of the importance of weighing the potential benefits and risks of medications before prescribing them, particularly in individuals with pre-existing cardiac conditions.
Date :
  1. Date Completed 2012-01-05
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21892192

DOI: Digital Object Identifier

PMC4003299

Related Literature

Article Analysis
・Effects of hydroxyzine
SNS
PICO Info
in preparation
Languages

English

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