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Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial.

Author: CappielloFulvio, Di CelloAnnalisa, FalboAngela, PalombaStefano, TolinoAchille, ZulloFulvio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a randomized, double-blind, placebo-controlled trial of 88 patients with polycystic ovary syndrome (PCOS) and reduced ovarian reserve undergoing in vitro fertilization (IVF), metformin worsened the ovarian response to gonadotropins. This suggests that metformin should be stopped before the start of controlled ovarian hyperstimulation for IVF programs in patients with PCOS and reduced ovarian reserve.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the effects of metformin on the ovarian response to gonadotropins given for in vitro fertilization (IVF) programs in patients with polycystic ovary syndrome (PCOS) and reduced ovarian reserve. DESIGN: Prospective, parallel, randomized, double-blind, placebo-controlled clinica...See full text at original site
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引用元：
https://doi.org/10.1016/j.fertnstert.2011.08.020

データ提供：米国国立医学図書館（NLM）

Exploring the Impact of Metformin on Ovarian Response in PCOS Patients

This randomized controlled trial examines the effects of metformin, a medication commonly used for managing type 2 diabetes, on ovarian response to gonadotropins, hormones used to stimulate egg production, in women with polycystic ovary syndrome (PCOS) and reduced ovarian reserve. The researchers aimed to assess whether metformin could improve the success rates of in vitro fertilization (IVF) by enhancing ovarian response. Their findings, however, revealed that metformin worsened ovarian response, leading to a higher cancellation rate for low ovarian response in the metformin group.

Metformin May Not Be Beneficial for IVF in PCOS Patients with Reduced Ovarian Reserve

The study's findings suggest that metformin may not be an effective or even beneficial treatment for PCOS patients with reduced ovarian reserve undergoing IVF. The researchers found that metformin negatively impacted ovarian response, leading to decreased egg production and a higher risk of IVF cycle cancellation.

Health and Lifestyle Implications

The study highlights the importance of carefully considering the potential risks and benefits of metformin in PCOS patients with reduced ovarian reserve who are undergoing IVF. Healthcare professionals should carefully evaluate individual patient factors and make informed decisions regarding metformin use in this context.

Dr. Camel's Conclusion

This study provides valuable insights into the complex interaction between metformin and ovarian response in PCOS patients. It emphasizes the importance of individualized patient care, considering each patient's specific needs and potential risks and benefits of different treatment options. As a researcher, I find this study crucial for improving our understanding of PCOS and optimizing IVF treatment outcomes.
Date :
  1. Date Completed 2011-12-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21917254

DOI: Digital Object Identifier

10.1016/j.fertnstert.2011.08.020

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

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