Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine in seronegative children.

Author: , AbughaliNazha, BernsteinDavid I, DubovskyFilip, FalloonJudith, MalkinElissa, YiTingting

Paper Details 
Original Abstract of the Article :
BACKGROUND: Respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are important causes of lower respiratory tract illness and hospitalization in young children. Currently, there is no licensed vaccine against RSV or PIV3. METHODS: In this randomized, phase 1, double-blind, placebo...See full text at original site
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引用元:
https://doi.org/10.1097/INF.0b013e31823386f1

データ提供:米国国立医学図書館(NLM)

A New Hope for Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) Vaccines

The world of [vaccination research] is a vast desert, with many challenges to overcome. This study, like a camel traversing the dunes, seeks to find an oasis of hope for young children suffering from [RSV and PIV3 infections]. The researchers used a [randomized, phase 1, double-blind, placebo-controlled, dose-escalating study] to evaluate the [safety and immunogenicity] of a [live, attenuated RSV/PIV3 chimeric virus vaccine candidate] (MEDI-534). They found that MEDI-534 was [well-tolerated] with no significant differences in adverse events between the vaccine and placebo groups. The vaccine was also found to be [immunogenic], with the highest serologic response observed in the group receiving the [10 dosage] of the vaccine.

A Promising Step Towards a New Vaccine

This research holds much promise for the future of [childhood vaccinations]. The fact that MEDI-534 was well tolerated and generated an immune response in this study is a great sign for its continued development. It gives us hope for a future where [RSV and PIV3] infections are no longer a threat to the youngest members of our society.

A Healthy Future for Children

This study is a reminder of the importance of [vaccination] in protecting children from serious illnesses. With a safe and effective vaccine, we can create a healthier and brighter future for our children. Just like a camel navigating the desert, we must continue to persevere in our quest to find solutions to the challenges we face.

Dr.Camel's Conclusion

This study is a testament to the power of research in finding solutions to complex health challenges. The development of a safe and effective vaccine for RSV and PIV3 would be a significant victory for public health, and I'm excited to see this research continue to evolve!

Date :
  1. Date Completed 2012-05-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21926667

DOI: Digital Object Identifier

10.1097/INF.0b013e31823386f1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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