Dose-response evaluation of the amnestic effects of triazolam and pentobarbital in normal subjects.

Author: GriffithsR R, KirkT, RoacheJ D

Paper Details 
Original Abstract of the Article :
The effects of placebo, triazolam (0.25, 0.5, and 0.75 mg), and pentobarbital (100, 200, and 300 mg) were examined in seven normal male volunteers using a double-blind, Latin Square, balanced crossover design. Before and at hourly intervals after oral drug administration at approximately 10 a.m., su...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2198294

データ提供:米国国立医学図書館(NLM)

Unveiling the Amnestic Effects of Triazolam and Pentobarbital: A Dose-Response Study

The amnestic effects of [triazolam] and [pentobarbital] are well-documented, but the specific mechanisms and dose-response relationships remain poorly understood. This study aimed to investigate the amnestic effects of these drugs in a controlled setting, using a [double-blind, Latin Square, balanced crossover design] to compare the effects of different doses in healthy volunteers.

Dose-Related Impairment of Memory Performance

The study found that both [triazolam] and [pentobarbital] produced dose-related impairments in [memory performance], as measured by [number recall tasks]. The study further revealed that [triazolam] was significantly more potent than [pentobarbital] in inducing [memory impairment], especially at longer delay intervals. These findings underscore the importance of considering the [dose] and [duration of action] of these drugs when used in clinical settings.

Navigating the Labyrinth of Memory: Dr. Camel's Perspective

As a camel who has traversed the vast and often confusing deserts, I am familiar with the importance of a sharp memory. Navigating the sands requires remembering landmarks, water sources, and the paths that lead to safety. This study reminds us that certain medications can significantly impair our ability to form and retrieve memories. While [triazolam] and [pentobarbital] are valuable tools in medicine, their use should be carefully considered, particularly when [memory impairment] is a concern. As a camel who has learned to rely on my memory to survive, I urge everyone to use these medications responsibly and to be mindful of their potential effects on cognitive function.

Dr.Camel's Conclusion

This study offers valuable insights into the dose-response relationship of [triazolam] and [pentobarbital] in impairing [memory performance]. The findings highlight the importance of careful consideration of [dose] and [duration of action] when prescribing these drugs, particularly in situations where [memory impairment] could pose a risk. As a camel who has wandered through the deserts of knowledge, I am reminded that even the most powerful tools can have unintended consequences if used without caution. The journey to understanding the intricate workings of the human mind is long and complex, but it is a journey worth taking to ensure that we use these tools safely and responsibly.

Date :
  1. Date Completed 1990-09-05
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

2198294

DOI: Digital Object Identifier

2198294

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Languages

English

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