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Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis.

Author: AlmonRichard R, DuboisDebra C, JuskoWilliam J, LiuDongyang, LonHoi-Kei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anakinra, an IL-1β inhibitor, had modest effects on paw edema in collagen-induced arthritic rats.
Paper Details　
Original Abstract of the Article :
A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in collagen-induced arthritic (CIA) rats and explore the role of interleukin-1β (IL-1β) in rheumatoid arthritis. The CIA rats received either vehicle, or anakinra ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22002845

データ提供：米国国立医学図書館（NLM）

Modeling Anakinra’s Effects on Collagen-Induced Arthritis

The study of [rheumatoid arthritis] has advanced significantly with a focus on understanding the role of [IL-1β] in disease progression. This study utilizes a [population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS)] model to investigate the effects of [anakinra] in [collagen-induced arthritic (CIA) rats]. The authors aim to characterize the drug's [pharmacokinetic] and [pharmacodynamic] properties and assess the role of [IL-1β] in [rheumatoid arthritis].

Unveiling the Dynamics of Anakinra in Arthritis

The model developed in this study effectively captures the [pharmacokinetic] and [pharmacodynamic] profiles of [anakinra] in [CIA rats]. The authors found that [anakinra] had [modest effects] on [paw edema], suggesting a potential role in managing [rheumatoid arthritis]. This research offers a valuable tool for understanding the complex interplay between [drug effects] and [disease progression].

Navigating the Desert of Rheumatoid Arthritis Treatment

The desert of [rheumatoid arthritis] treatment is constantly evolving, with new insights into disease mechanisms and therapeutic approaches. This study contributes to this evolving landscape by providing a detailed model of [anakinra]’s effects in [CIA rats]. This research paves the way for a more precise understanding of the drug’s efficacy and potential applications in managing [rheumatoid arthritis] in humans.

Dr.Camel's Conclusion

This study utilizes a [population PK/PD/DIS] model to investigate the effects of [anakinra] in [CIA rats]. The model effectively captures the drug’s [pharmacokinetic] and [pharmacodynamic] properties, providing insights into the complex interplay between [drug effects] and [disease progression]. This research offers valuable information for developing more effective and targeted therapies for [rheumatoid arthritis] in humans.

Date :
  1. Date Completed 2012-03-20
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

22002845

DOI: Digital Object Identifier

NIHMS392751

Related Literature

Article Analysis
・Effects of anakinra
SNS
PICO Info
in preparation
Languages

English

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