Paper Details

  1. Home
  2. Paper Details

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

Author: ChenMei, ChengChieh-Fang, FanJianhua, KimRosie, KuangYuting, LiWei, LiYong, O'BrienKathryn, SahuDivya, TsenFred, WangXinyi, WoodleyDavid T, ZhaoZhengwei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

A 115-aa fragment of secreted Hsp90α promoted wound closure more effectively than PDGF-BB in both acute and diabetic wounds.
Paper Details　
Original Abstract of the Article :
Wounds that fail to heal in a timely manner, for example, diabetic foot ulcers, pose a health, economic, and social problem worldwide. For decades, conventional wisdom has pointed to growth factors as the main driving force of wound healing; thus, growth factors have become the center of therapeutic...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204835/

データ提供：米国国立医学図書館（NLM）

A New Frontier in Wound Healing: The Potential of Hsp90α

The healing process is an intricate dance of cells, growth factors, and signaling pathways. This study delves into the fascinating world of wound healing, focusing specifically on the role of heat shock protein 90α (Hsp90α). The researchers investigate the potential of a 115-amino acid fragment of secreted Hsp90α, dubbed F-5, as a novel wound healing agent. This study sheds light on the complex mechanisms involved in wound repair and explores the potential of unconventional wound healing therapies.

A New Oasis in the Desert of Wound Healing: F-5

The findings of this study are truly groundbreaking! The researchers found that F-5 peptide promoted both acute and diabetic wound closure in mice more effectively than the current FDA-approved growth factor therapy, becaplermin. This suggests that F-5 has the potential to revolutionize wound healing treatment.

The Promise of F-5: A Healing Oasis

The desert of wound healing can be a long and arduous journey. This study offers a glimmer of hope for those struggling with slow-healing wounds, particularly diabetic foot ulcers. The researchers highlight the potential of F-5 as a novel wound healing agent, demonstrating its ability to promote both epidermal and dermal cell migration. This discovery could lead to the development of more effective and safer treatments for a wide range of wounds, improving the quality of life for countless individuals.

Dr.Camel's Conclusion

This study offers a refreshing oasis in the desert of wound healing. The discovery of F-5, a fragment of secreted Hsp90α, opens a new chapter in wound healing research. This novel agent has the potential to revolutionize wound care, offering a more effective and safer alternative to current therapies. The study provides a beacon of hope for those suffering from chronic wounds, paving the way for a brighter future in wound healing.

Date :
  1. Date Completed 2012-01-03
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

22019588

DOI: Digital Object Identifier

PMC3204835

Related Literature

Article Analysis
・Effects of becaplermin topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.