Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine.

Author: ColemanA L, EngerC, MayerP R, PollackI P, RobinA L, RudikoffM T

Paper Details 
Original Abstract of the Article :
We performed a double-masked, crossover study comparing the cardiovascular and intraocular pressure effects of 0.5% and 0.25% topical apraclonidine hydrochloride and 0.5% timolol maleate in 20 healthy female volunteers. The contralateral effects of unilateral apraclonidine and the plasma concentrati...See full text at original site
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引用元:
https://doi.org/10.1001/archopht.1990.01070110080029

データ提供:米国国立医学図書館(NLM)

Apraclonidine: A Cool Oasis in the Desert of High Intraocular Pressure

High intraocular pressure (IOP), a major risk factor for glaucoma, can be a challenging condition, like a desert heatwave that can damage the delicate tissues of the eye. Apraclonidine, a medication that lowers IOP, acts like a refreshing breeze in the desert, providing temporary relief from the pressure. But like a mirage, the effectiveness of apraclonidine can vary, and its cardiovascular effects have been a topic of discussion, like the whispers of wind across the sands. This study, a meticulous investigation into the desert of apraclonidine's effects, aimed to compare the cardiovascular and IOP effects of different doses of apraclonidine and timolol, another IOP-lowering medication.

Apraclonidine: A Balanced Approach in the Desert of IOP

This research, a scientific expedition into the desert of ocular pressure, provides valuable insights into the effects of apraclonidine. The study found that apraclonidine, in both 0.5% and 0.25% concentrations, lowered IOP effectively without significantly affecting blood pressure or heart rate. While timolol did blunt exercise-induced tachycardia, apraclonidine showed no significant cardiovascular effects, demonstrating its potential as a safe and effective treatment option.

Managing IOP: Navigating the Desert with Caution

This research highlights the potential benefits of apraclonidine for managing IOP. However, it's important to note that this study involved a small sample size and further research is needed to confirm these findings. Individuals with high IOP should consult with an ophthalmologist to discuss their specific situation and explore available treatment options.

Dr. Camel's Conclusion

This study, a careful exploration of the desert of apraclonidine's effects, provides valuable insights into its potential as a safe and effective treatment for high IOP. While more research is needed to fully understand its long-term effects, the findings suggest that apraclonidine may offer a balanced approach to managing IOP, minimizing potential cardiovascular risks.

Date :
  1. Date Completed 1990-10-15
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

2205182

DOI: Digital Object Identifier

10.1001/archopht.1990.01070110080029

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