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Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.

Author: AntelJ, HebebrandJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Topiramate and zonisamide, two antiepileptic drugs, can cause significant weight loss. This review discusses potential molecular mechanisms responsible for this effect and examines clinical studies on these drugs.
Paper Details　
Original Abstract of the Article :
Drug-induced weight alteration can be a serious side effect that applies to several therapeutic agents and must be referred to in the respective approved labeling texts. The side effect may become health threatening in case of significant weight change in either direction. Several antiepileptic drug...See full text at original site
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引用元：
https://doi.org/10.1007/978-3-642-24716-3_20

データ提供：米国国立医学図書館（NLM）

Topiramate and Zonisamide: Weight Loss in the Desert of Epilepsy Treatment

Weight changes are a common side effect of many medications, including antiepileptic drugs (AEDs). This chapter focused on two AEDs, topiramate and zonisamide, known for their weight-reducing effects. The authors explored the potential mechanisms of action responsible for these effects, drawing upon both in vivo studies in animal models and clinical trials in human patients.

Exploring the Mechanism: Unveiling the Desert's Secrets

The review delved into the potential mechanisms of action responsible for topiramate and zonisamide's weight-reducing effects. These mechanisms involve a complex interplay of factors, including appetite regulation, metabolic processes, and neurotransmitter modulation. The review also summarized clinical studies exploring these drugs as single entities or in combination with other agents, providing valuable insights into their effectiveness and potential side effects.

Navigating the Weight Loss Landscape

This chapter, like a guidebook for navigating a complex and often unpredictable desert, provides valuable insights into the weight-reducing effects of topiramate and zonisamide. The review summarizes the potential mechanisms of action, highlighting the need for further research to fully understand these complex processes. The review also underscores the importance of considering potential weight loss when prescribing these medications, particularly in patients with pre-existing eating disorders or weight concerns.

Dr. Camel's Conclusion

This chapter, like a compass guiding us through the desert of epilepsy treatment, provides a comprehensive overview of the weight-reducing effects of topiramate and zonisamide. The review highlights the importance of understanding these effects and considering them in clinical practice.

Date :
  1. Date Completed 2012-04-25
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

22249827

DOI: Digital Object Identifier

10.1007/978-3-642-24716-3_20

SNS
PICO Info
in preparation
Languages

English

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