Paper Details
- Home
- Paper Details
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.
Author: ChapyHélène, MaengHan-Joo, PangK Sandy, ZamanSarah
Original Abstract of the Article :
Effects of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), natural ligand of the VDR, on the fates of adefovir dipivoxil (P-gp substrate) and its metabolites, mono(POM)-PMEA and adefovir (MRP4 substrate), were investigated in Caco-2 cells. After 1,25(OH)2D3-treatment, higher apical efflux of adefovir was o...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ejps.2012.02.018
データ提供:米国国立医学図書館(NLM)
The Impact of Vitamin D on Adefovir Dipivoxil: A Journey Through the Desert of Drug Metabolism
The human body is a complex desert, with intricate pathways and mechanisms governing drug metabolism. This research, like a curious explorer venturing into the unknown, investigates the impact of [research methodology] to explore [research objectives]. The authors discovered [main findings] highlighting the potential role of vitamin D in drug interactions. The results demonstrate the [remarkable results or significance] of vitamin D on the transport and metabolism of adefovir dipivoxil.
Vitamin D and Adefovir Dipivoxil: A New Perspective on Drug Interactions
This research, like a map revealing hidden springs, provides valuable insights into the complex interplay between vitamin D and drug metabolism. The findings suggest that [social implications], highlighting the importance of considering the potential impact of vitamin D on drug efficacy and safety.
Navigating the Desert of Drug Interactions
As we journey through the vast desert of drug metabolism, it is crucial to understand the factors that can influence drug activity. This research, like a beacon of knowledge, sheds light on the potential impact of vitamin D on the transport and metabolism of adefovir dipivoxil, providing a deeper understanding of drug interactions and their implications for patient care.
Dr. Camel's Conclusion
This research, like a well-placed oasis in the desert of drug metabolism, provides valuable insights into the complex interaction between vitamin D and adefovir dipivoxil. It highlights the importance of considering the potential impact of vitamin D on drug efficacy and safety and underscores the need for further research in this area.
Date :
- Date Completed 2012-08-02
- Date Revised 2018-12-01
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.