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Activity of oxacillin versus that of vancomycin against oxacillin-susceptible mecA-positive Staphylococcus aureus clinical isolates evaluated by population analyses, time-kill assays, and a murine thigh infection model.

Author: LabrouMaria, MichailGeorge, NtokouEleni, PittarasTheodore E, PournarasSpyros, TsakrisAthanassios

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the activity of dicloxacillin and vancomycin against 15 oxacillin-susceptible, methicillin-resistant Staphylococcus aureus (OS-MRSA) isolates. Both drugs exhibited similar bactericidal activity. Dicloxacillin was effective in 10 isolates and vancomycin was effective in 12 isolates. The findings suggest that dicloxacillin, an antistaphylococcal penicillin, may be a viable option for treating OS-MRSA infections.
Paper Details　
Original Abstract of the Article :
We compared the activity of dicloxacillin with that of vancomycin against 15 oxacillin-susceptible, methicillin-resistant Staphylococcus aureus (OS-MRSA) clinical isolates. By population analyses, we found that 6 OS-MRSA isolates were able to grow in the presence of up to 8 μg/ml dicloxacillin and 9...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370787/

データ提供：米国国立医学図書館（NLM）

Oxacillin vs. Vancomycin: A Tale of Two Antibiotics

Antimicrobial resistance is a growing challenge in healthcare, requiring ongoing research to identify effective treatment options for bacterial infections. This research compares the activity of oxacillin and vancomycin against oxacillin-susceptible, methicillin-resistant Staphylococcus aureus (OS-MRSA) isolates, exploring the potential of oxacillin for treating these infections.

A New Pathway Through the Desert of Resistance

This study delves into the complexities of antimicrobial resistance, exploring the potential of oxacillin for treating OS-MRSA infections. The findings suggest that oxacillin may be a viable alternative to vancomycin, demonstrating comparable efficacy in some cases. This research provides valuable insights into the potential of oxacillin for managing OS-MRSA infections, offering a potential new pathway through the desert of resistance.

A Glimpse of Hope in the Sands of Resistance

This research offers a glimmer of hope in the sands of resistance, suggesting a potential alternative to vancomycin for treating OS-MRSA infections. The findings highlight the importance of continued research into alternative antimicrobial agents, expanding our arsenal for combating the challenge of bacterial resistance.

Dr. Camel's Conclusion

This research, like a caravan seeking a route through a vast desert of resistance, explores the potential of oxacillin for treating OS-MRSA infections. The findings suggest that oxacillin may offer a viable alternative to vancomycin, providing a potential new pathway for managing these challenging infections.

Date :
  1. Date Completed 2012-09-13
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22430957

DOI: Digital Object Identifier

PMC3370787

Related Literature

Article Analysis
・Effects of dicloxacillin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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