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Comparative extrapyramidal effects of Rauwolfia vomitoria, chlorpromazine and reserpine in mice.
Author: BisongSunday Agba, BrownRichard Earl, OsimEme Effiom
Original Abstract of the Article :
Most antipsychotics interfere with the dopaminergic system, resulting in extrapyramidal effects. This study compared the extrapyramidal effects of chlorpromazine (Cpz), the herb Rauwolfia vomitoria (RV) and its alkaloid reserpine (Res), used as antipsychotics, in mice. Ninety age-matched male CD-1 s...See full text at original site
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引用元:
https://doi.org/10.1007/s11418-012-0657-8
データ提供:米国国立医学図書館(NLM)
Antipsychotics and Extrapyramidal Effects: Navigating the Desert of Neurological Side Effects
The world of antipsychotic medication is a complex and often unpredictable landscape, like a vast desert with hidden dangers and unforeseen challenges. This research delves into the extrapyramidal effects, a group of neurological side effects, associated with antipsychotics. The researchers sought to compare the extrapyramidal effects of chlorpromazine, Rauwolfia vomitoria, and reserpine, three antipsychotic agents. This is like a group of explorers venturing into the desert, each equipped with a different set of tools and strategies for navigating its treacherous terrain.
The researchers found that both chlorpromazine and reserpine induced extrapyramidal effects in mice, while Rauwolfia vomitoria had a significantly lower incidence of these side effects. This is like discovering that one explorer's tools are more effective in avoiding the dangers of the desert, leading to a safer and more successful journey.
A New Oasis of Hope: Rauwolfia vomitoria as a Potential Antipsychotic
The study suggests that Rauwolfia vomitoria, a natural herb, may have potential as a safer antipsychotic agent compared to chlorpromazine and reserpine. This is a significant finding, as it opens up new possibilities for treating psychotic disorders with fewer neurological side effects. This is like discovering a new oasis that offers respite from the harsh realities of the desert, providing a haven of peace and well-being.
Dr. Camel's Conclusion
This research underscores the importance of exploring natural remedies for psychotic disorders. The findings suggest that Rauwolfia vomitoria may offer a safer and more effective alternative to existing antipsychotics. However, further research is needed to confirm these findings in humans. This research serves as a valuable reminder that the desert of scientific exploration often yields unexpected treasures, offering hope and healing for those in need.
Date :
- Date Completed 2013-05-22
- Date Revised 2022-03-31
Further Info :
Related Literature
English
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