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The effects of systemic, topical, and intralesional steroid treatments on apoptosis level of nasal polyps.

Author: BerberUfuk, CekinEngin, CincikHakan, ErkulBulent Evren, GungorAtila, KapucuBurak

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Systemic, topical, and intrapolyp injection of glucocorticoids increased apoptotic index in nasal polyps compared to no treatment, with systemic steroids showing the highest effect.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The purpose of this study was to compare the apoptotic responses to systemic, topical, and intrapolyp injection of glucocorticoid with no treatment in nasal polyps. STUDY DESIGN: Prospective, randomized controlled study. SETTING: Tertiary training hospital. SUBJECTS AND METHODS: The st...See full text at original site
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引用元：
https://doi.org/10.1177/0194599812446678

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Systemic, Topical, and Intralesional Steroid Treatments on Apoptosis in Nasal Polyps

This study compares the apoptotic responses of nasal polyps to systemic, topical, and intralesional steroid treatments. The authors used the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method to assess apoptosis in nasal polyps. This study compares the apoptotic responses of nasal polyps to systemic, topical, and intralesional steroid treatments, using the TUNEL method to assess apoptosis.

Steroid Treatment Induces Apoptosis in Nasal Polyps

This study demonstrates that all three forms of steroid treatment, systemic, topical, and intralesional, induce apoptosis in nasal polyps. Systemic steroid treatment was found to be most effective in inducing apoptosis. This study demonstrates that all three forms of steroid treatment, systemic, topical, and intralesional, induce apoptosis in nasal polyps, with systemic steroid treatment being the most effective in inducing apoptosis.

Implications for the Treatment of Nasal Polyposis

This study provides valuable information for the treatment of nasal polyposis. The findings suggest that steroids, particularly systemic steroids, can effectively induce apoptosis in nasal polyps, leading to potential improvements in symptoms.

Dr.Camel's Conclusion

This study takes us on a journey through the desert of nasal polyposis, uncovering the role of steroids in promoting apoptosis. The researchers discovered that steroids, like a refreshing oasis, can induce cell death in nasal polyps, potentially leading to symptom relief. This study's findings, like a guidepost leading to a hidden spring, offer valuable insight for clinicians treating patients with nasal polyposis.
Date :
  1. Date Completed 2012-11-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22555894

DOI: Digital Object Identifier

10.1177/0194599812446678

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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