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A presumptive role for GABA in the stimulatory effects of Des-Gly10, [D-Ala6]-LHRH-ethylamide and pimozide on the gonadotropin release in carp.

Author: BieniarzK, BretonB, EplerP, MikolajczykT, OllevierF, RoelantsI

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Gamma-aminobutyric acid (GABA) was found to interact with the action of dopamine and gonadotropin releasing hormone (GnRH) on the release of gonadotropin (GtH) in carps. In female carps, an inhibitor of GABA biosynthesis enhanced the GtH response to pimozide and LHRH-a. In male carps, a GABA-ergic compound decreased LHRH-a stimulated GtH levels.
Paper Details　
Original Abstract of the Article :
To investigate the effect of endogenous gamma-aminobutyric acid (GABA) on the blood maturating gonadotropin (GtH) levels, or to study its interaction with pimozide (dopamine antagonist) and a luteinizing hormone-releasing hormone analog (LHRH-a), sexually mature male and female carps were treated wi...See full text at original site
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引用元：
https://doi.org/10.1016/0024-3205(90)90282-v

データ提供：米国国立医学図書館（NLM）

GABA: A Potential Key to Gonadotropin Release in Carp

The intricate workings of the human body are a source of constant fascination and exploration. This study delves into the role of gamma-aminobutyric acid (GABA) in regulating gonadotropin release in carp, a type of fish. The researchers investigated the effects of GABA on gonadotropin release, studying its interactions with dopamine and luteinizing hormone-releasing hormone (LHRH). They experimented with drugs that either inhibited or enhanced GABA production and observed their impact on gonadotropin levels. The results suggest that GABA interacts with dopamine and LHRH, influencing gonadotropin release in carp. This research provides insights into the complex neuroendocrine mechanisms regulating reproductive processes in fish.

Unveiling the Secrets of Gonadotropin Release

The study provides valuable insights into the role of GABA in regulating gonadotropin release in carp. This research contributes to a better understanding of the complex neuroendocrine mechanisms that control reproductive processes in fish.

Navigating the Labyrinth of Reproductive Biology: The Role of GABA

This research underscores the importance of understanding the intricate interplay of neurotransmitters and hormones in regulating reproductive processes. It highlights the potential role of GABA in influencing gonadotropin release and provides a foundation for further exploration of its role in reproductive biology.

Dr.Camel's Conclusion

GABA plays a role in regulating gonadotropin release in carp, interacting with dopamine and LHRH. This research provides a valuable contribution to our understanding of the complex neuroendocrine mechanisms underlying reproductive processes in fish.
Date :
  1. Date Completed 1991-01-30
  2. Date Revised 2019-07-01
Further Info :

Pubmed ID

2259268

DOI: Digital Object Identifier

10.1016/0024-3205(90)90282-v

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・Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

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