Paper Details

  1. Home
  2. Paper Details

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment.

Author: CraigLori B, LofwallMichelle R, NuzzoPaul A, SiegelAnthony J, StoopsWilliam W, WalshSharon L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Naltrexone blocked the mu opioid agonist-like effects of hydromorphone, but only partially attenuated tramadol's positive subjective effects, suggesting both mu and non-mu opioid actions contribute to its profile of action.
Paper Details　
Original Abstract of the Article :
RATIONALE: Tramadol is a prescription analgesic that activates mu opioid and monoamine receptor systems. Tramadol is thought to have limited abuse potential compared to mu opioid agonists, but laboratory data indicate that it shares some of their pharmacodynamic effects. OBJECTIVES: This study eval...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/22623016

データ提供：米国国立医学図書館（NLM）

Unveiling the Pharmacodynamic Profile of Tramadol: A Journey into the Desert of Opioid Action

Tramadol, a prescription analgesic, presents a complex pharmacological profile, activating both mu opioid and monoamine receptor systems. This research investigates the effect of mu opioid receptor blockade with naltrexone on the pharmacodynamic action of tramadol in humans. The study found that naltrexone partially reversed the physiological effects of tramadol, suggesting that both mu and non-mu opioid actions contribute to its subjective profile of action. The study highlights the need for further research to better understand the complex mechanisms underlying the pharmacological effects of tramadol.

The Desert of Opioid Action: Exploring the Complexities of Tramadol

Tramadol, like a desert oasis, offers relief from pain, but its effects can be complex and challenging to understand. This research delves into the intricate pharmacological actions of tramadol, revealing the role of both mu and non-mu opioid receptor systems in its effects.

Navigating the Desert of Analgesic Treatment

Pain management, like navigating a vast desert, often involves complex treatment strategies. This research helps us understand the complexities of tramadol, providing insights into its potential benefits and risks. The study highlights the importance of a comprehensive approach to pain management, considering the nuances of individual patient responses and the interactions between different medication classes.

Dr.Camel's Conclusion

This study delves into the fascinating world of tramadol's pharmacological actions, revealing the complex interplay of opioid receptors and its subjective effects. The research underscores the importance of considering the full spectrum of tramadol's effects and its potential interactions with other medications when prescribing it. Further research is needed to fully understand the mechanisms underlying its diverse pharmacological profile, paving the way for more effective and targeted treatment strategies.
Date :
  1. Date Completed 2013-02-13
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22623016

DOI: Digital Object Identifier

NIHMS380999

Related Literature

Article Analysis
・Effects of tramadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.