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Old and new therapeutic developments in steroid treatment in Duchenne muscular dystrophy.

Author: AngeliniCorrado, PeterleEnrico

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Steroids have been shown to be effective in treating Duchenne muscular dystrophy (DMD) and are widely used to improve muscle function. While they can prolong ambulation, concerns remain about their side effects and toxicity.
Paper Details　
Original Abstract of the Article :
Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation of ambulation but with different si...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440806/

データ提供：米国国立医学図書館（NLM）

Duchenne Muscular Dystrophy: Exploring Steroid Treatment Strategies

Duchenne muscular dystrophy (DMD), a genetic disorder that affects muscle function, poses significant challenges for treatment. This research delves into the use of steroids in DMD, examining the efficacy and potential side effects of various steroid regimens. The authors explore the ongoing efforts to optimize steroid treatment strategies, aiming to maximize therapeutic benefits while minimizing adverse effects.

Steroids in DMD: Balancing Benefits and Risks

The study highlights the established efficacy of steroids in improving muscle function and extending ambulation in DMD patients. However, the authors acknowledge the need for further research to minimize steroid-related side effects and toxicity. They discuss the potential benefits of alternative steroid regimens, such as intermittent glucocorticoids, and the ongoing clinical trial comparing different steroid therapies. This research emphasizes the importance of tailoring steroid therapy to individual patient needs to optimize outcomes and minimize side effects.

Navigating DMD Treatment: A Complex and Evolving Landscape

This research underscores the ongoing efforts to find effective and safe treatments for DMD. The authors highlight the need for continued research to develop novel therapies that can address the underlying genetic defect and improve the long-term outcomes for patients with DMD. The research emphasizes the importance of ongoing clinical trials to compare different treatment strategies and identify the most effective options for patients.

Dr.Camel's Conclusion

DMD is a tough challenge, like navigating a desert with shifting sands. This research explores the use of steroids as a tool for managing DMD symptoms. Just as a camel needs to find the right path through the desert, patients with DMD need individualized treatment strategies to maximize their quality of life. This is a reminder that the search for effective treatments for DMD continues, with ongoing research and clinical trials paving the way for better outcomes in the future.

Date :
  1. Date Completed 2012-07-19
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

22655511

DOI: Digital Object Identifier

PMC3440806

SNS
PICO Info
in preparation
Languages

English

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