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Determination of ofloxacin in tear by HPLC-ESI-MS/MS method: comparison of ophthalmic drug release between a new mucoadhesive chitosan films and a conventional eye drop formulation in rabbit model.

Author: ByrroRicardo Martins Duarte, ChelliniPaula Rocha, CésarIsabela Costa, PianettiGerson Antônio, da Silva CunhaArmando, de Oliveira FulgêncioGustavo

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A validated HPLC-ESI-MS/MS method was developed to quantify ofloxacin in rabbit tears. This method was used to assess the concentration of ofloxacin in tears after treatment with mucoadhesive chitosan films and conventional eye drops.
Paper Details　
Original Abstract of the Article :
Ofloxacin, second-generation fluoroquinolone derivative, is one of the most commonly used to treat and prevent superficial ocular infection in animals and human beings. However, poor bioavailability, rapid elimination, and non compliance by patients are several problems associated with ocular route....See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2012.05.003

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2013-02-07
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

22673938

DOI: Digital Object Identifier

10.1016/j.jpba.2012.05.003

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・Side Effects of ofloxacin
SNS
PICO Info
in preparation
Languages

English

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