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Low intrinsic drug activity and dominant vehicle (placebo) effect in the topical treatment of acne vulgaris.

Author: ChiouWin L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that the effectiveness of 8 commonly used topical acne treatments could be significantly influenced by the inactive ingredients (vehicle) in the products, rather than just the active drug itself. After 10-12 weeks of daily use, the vehicle contributed an average of 55% (ranging from 35% to 82%) to the overall reduction in acne lesions. This was especially notable for benzoyl peroxide products, where the vehicle contributed up to 89% of the effect. This research suggests that the inactive ingredients play a significant role in topical acne treatments and should be considered when developing more effective treatments.
Paper Details　
Original Abstract of the Article :
In drug treatment for acne, topical products alone or in combination with systemic products are commonly prescribed. It was recently pointed out by Chiou that oral tetracyclines, the most commonly prescribed systemic drugs, may not be as effective as commonly assumed because the effect of placebo ca...See full text at original site
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引用元：
https://doi.org/10.5414/cp201694

データ提供：米国国立医学図書館（NLM）

Low Intrinsic Drug Activity and Dominant Vehicle (Placebo) Effect in the Topical Treatment of Acne Vulgaris

Acne vulgaris, a common skin condition characterized by blemishes and inflammation, is a source of frustration for many individuals. This study delves into the fascinating world of topical acne treatments, exploring the role of placebo effects in driving perceived efficacy. The researchers embarked on a journey to evaluate the relative contributions of active ingredients and vehicle (placebo) effects in commonly prescribed topical acne medications, seeking to understand the true effectiveness of these treatments.

Placebo Effects in Topical Acne Treatment

The study's findings revealed a surprising revelation—the placebo effect played a significant role in the perceived effectiveness of topical acne medications. The results demonstrated that vehicle effects, or placebo effects, accounted for a substantial portion of the reported reduction in acne lesions. These findings challenge conventional assumptions about the efficacy of topical acne treatments, suggesting that the true effectiveness of active ingredients may be less than previously believed.

Unmasking the Truth Behind Acne Treatments

The desert of acne can be a difficult landscape to navigate. This study provides valuable insights into the role of placebo effects in shaping the perception of acne treatment effectiveness. By understanding the true contributions of active ingredients and placebo effects, we can develop more effective and targeted treatments for acne, ensuring that patients receive the best possible care. Think of this research as a mirror, reflecting the true nature of acne treatments and helping us see beyond the illusion of placebo effects.

Dr.Camel's Conclusion

This study unveils the significant role of placebo effects in topical acne treatment. The findings challenge conventional assumptions about the effectiveness of these medications and highlight the need for further research to identify truly effective treatments. Think of this research as a journey through the desert of acne, where we uncover the hidden truths about the effectiveness of various treatments.

Date :
  1. Date Completed 2012-07-31
  2. Date Revised 2019-06-08
Further Info :

Pubmed ID

22677304

DOI: Digital Object Identifier

10.5414/cp201694

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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