Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia.

Author: ArthurChristopher, BucksteinRena, CermakJaroslav, ChouWen-Chien, DelaunayJacques, DmoszynskaAnna, FaderlStefan, GauJyh-Pyng, KantarjianHagop M, KuoChing-Yuan, LysákDaniel, MayerJiri, MazurGrzegorz, MindenMark, OriolAlbert, RavandiFarhad, ThomasXavier G, WierzbowskaAgnieszka

Paper Details 
Original Abstract of the Article :
PURPOSE: This multicenter, randomized, open-label, phase III trial compared the efficacy and safety of decitabine with treatment choice (TC) in older patients with newly diagnosed acute myeloid leukemia (AML) and poor- or intermediate-risk cytogenetics. PATIENTS AND METHODS: Patients (N = 485) age ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874148/

データ提供:米国国立医学図書館(NLM)

Decitabine vs. Patient Choice for Older Patients with Newly Diagnosed Acute Myeloid Leukemia

This research compares the efficacy and safety of decitabine with patient choice (TC) in older patients with newly diagnosed acute myeloid leukemia (AML). The study uses a multicenter, randomized, open-label design, assigning patients to receive either decitabine or TC, which included either supportive care or low-dose cytarabine. The researchers found that decitabine improved response rates compared to TC, without major differences in safety. This study provides valuable insights into the optimal treatment strategies for older patients with AML, highlighting the potential benefits of decitabine.

New Hope for Older Patients with AML

This study offers hope for older patients with AML, demonstrating that decitabine can improve response rates compared to standard therapies. The researchers' findings suggest that decitabine could be a valuable treatment option for this challenging disease, potentially extending survival and improving quality of life for older patients. This study underscores the importance of ongoing research and development of new therapies for AML, ultimately improving patient outcomes and survival.

Navigating Cancer Treatment: A Multi-Disciplinary Approach

This research highlights the need for a multi-disciplinary approach to managing cancer, involving a team of healthcare professionals who can tailor treatment plans to individual patient needs. It's essential for patients to discuss treatment options with their healthcare providers and to engage in open communication about potential side effects and challenges. Just as a camel relies on its caravan for support during a desert journey, patients with cancer can find strength and guidance from a dedicated medical team. This research offers a glimmer of hope for older patients with AML, suggesting that decitabine could be a valuable tool in their fight against this challenging disease.

Dr.Camel's Conclusion

This research offers hope for older patients with AML, demonstrating that decitabine can improve response rates without major differences in safety. It's a reminder that the desert of cancer treatment is vast and complex, but with ongoing research and innovation, we can find pathways to better treatment options and improved outcomes. Just as a camel adapts to the changing desert landscape, healthcare professionals must adapt their treatment strategies to meet the unique needs of each patient. This study highlights the importance of ongoing research and collaboration in the fight against cancer.

Date :
  1. Date Completed 2012-09-24
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

22689805

DOI: Digital Object Identifier

PMC4874148

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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