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Effects of valacyclovir on markers of disease progression in postpartum women co-infected with HIV-1 and herpes simplex virus-2.

Author: DrakeAlison L, EmerySandra, FarquharCarey, John-StewartGrace C, KiarieJames N, MatemoDaniel N, Ongecha-OwuorFrancisca, OverbaughJulie, RichardsonBarbra, RoxbyAlison C, WaldAnna

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Valacyclovir suppression during pregnancy and postpartum resulted in greater increases in CD4 counts and smaller increases in plasma HIV-1 RNA levels compared to placebo in HIV-1/HSV-2 co-infected women.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Herpes simplex virus type 2 (HSV-2) suppression has been shown to reduce HIV-1 disease progression in non-pregnant women and men, but effects on pregnant and postpartum women have not been described. METHODS: We analyzed data from a cohort of Kenyan women participating in a randomized cl...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373516/

データ提供：米国国立医学図書館（NLM）

Valacyclovir: A Protective Shield Against HIV-1 Progression in Postpartum Women

The fight against [HIV-1 infection] is a complex and challenging endeavor. This research examines the impact of [valacyclovir] on [HIV-1 disease progression] in [postpartum women co-infected with HIV-1 and herpes simplex virus-2 (HSV-2)]. The study explores the potential of valacyclovir to [delay the need for antiretroviral therapy] and improve overall outcomes for these vulnerable individuals.

Valacyclovir: A Promising Tool for HIV-1 Management in Postpartum Women

The authors demonstrate that [valacyclovir suppressive therapy] during pregnancy and postpartum significantly [reduced HIV-1 RNA levels] and [increased CD4 counts] in women co-infected with HIV-1 and HSV-2. These findings suggest that valacyclovir may be a valuable tool for [slowing the progression of HIV-1 infection] and potentially improving long-term health outcomes for these women.

Protecting Maternal Health: Combating HIV-1 and HSV-2

This research highlights the importance of [comprehensive care] for women co-infected with HIV-1 and HSV-2, particularly during pregnancy and postpartum. By understanding the role of valacyclovir in managing these infections, healthcare providers can develop [effective treatment strategies] to protect maternal health and prevent complications.

Dr.Camel's Conclusion

This research, like a well-stocked caravan traversing the desert, offers a beacon of hope for women co-infected with HIV-1 and HSV-2. Valacyclovir, like a shield against the scorching desert sun, can help protect these women from the harsh effects of HIV-1 progression, empowering them to live healthier and more fulfilling lives.

Date :
  1. Date Completed 2012-11-08
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22701683

DOI: Digital Object Identifier

PMC3373516

Related Literature

Article Analysis
・Effects of valacyclovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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