Effect of calcium channel blockers on experimentally induced seizures in rats.

Author: DavidJ, JosephT, KamalJ A, NadigR S

Paper Details 
Original Abstract of the Article :
Chemically different classes of calcium channel blockers were examined in rats for their effects on behavior, tolerability and protection against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures. In MES test at doses (mg/kg, ip) that were devoid of side effects, felod...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2272645

データ提供:米国国立医学図書館(NLM)

Calcium Channel Blockers: A New Approach to Seizure Control

This study explores the potential of calcium channel blockers to combat seizures, a condition that can be as unpredictable as a desert sandstorm. The study examines the effects of different classes of calcium channel blockers on chemically induced seizures in rats, finding that some of these drugs showed promising anticonvulsant activity. It's like finding a desert plant with unique properties that can help tame the wild winds.

Calcium Channel Blockers: A Potential New Frontier in Epilepsy Treatment

The study highlights the potential of calcium channel blockers as adjuvant therapeutic agents for epilepsy, particularly for patients who are resistant to conventional antiepileptic medications. It's like discovering a new tool in the desert explorer's kit, offering a potential solution for a challenging problem.

Calcium Channel Blockers: A Balancing Act in the Desert

While some calcium channel blockers showed promise in reducing seizures, the study also noted that some were associated with side effects, emphasizing the need for careful consideration and a balanced approach. It's like navigating a desert with both scorching sun and treacherous sand dunes, requiring careful attention to both risks and rewards.

Dr.Camel's Conclusion

This research opens up new possibilities for treating seizures, like a desert explorer stumbling upon a hidden oasis. Calcium channel blockers may offer a valuable addition to the arsenal of treatments for epilepsy, but further research is needed to fully understand their potential and navigate the challenging terrain of side effects.

Date :
  1. Date Completed 1991-02-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2272645

DOI: Digital Object Identifier

2272645

Related Literature

SNS
PICO Info
in preparation
Languages

English

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