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Effects of valproic acid and magnesium sulphate on rocuronium requirement in patients undergoing craniotomy for cerebrovascular surgery.

Author: DoS-H, HwangJ-W, JeonY-T, KimM-H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Valproic acid (VPA) increases the rocuronium requirement during surgery, but magnesium sulphate infusion can attenuate this effect.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Many anti-epileptics cause resistance to non-depolarizing neuromuscular blocking agents, but this has not been reported for valproic acid (VPA). We hypothesized that VPA would increase the rocuronium requirement and that magnesium sulphate (MgSO(4)) may reduce this increase. METHODS: Fi...See full text at original site
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引用元：
https://doi.org/10.1093/bja/aes218

データ提供：米国国立医学図書館（NLM）

Valproic Acid Can Increase Rocuronium Requirement in Patients Undergoing Craniotomy

Navigating the complex world of medications and their interactions is like navigating a vast desert – you need a compass and a keen eye for detail. This study investigated the effect of valproic acid (VPA), a common anti-epileptic drug, on the effectiveness of the muscle relaxant rocuronium. The study found that VPA actually increased the amount of rocuronium needed to achieve the desired muscle relaxation effect in patients undergoing craniotomy, a surgery on the skull.

Magnesium Sulfate Can Attenuate the Effect of Valproic Acid

The researchers then explored whether magnesium sulfate (MgSO4) could offset the increased rocuronium requirement caused by VPA. Their findings were promising: MgSO4 infusion significantly attenuated the increase in rocuronium requirement, suggesting a potential strategy for managing this drug interaction.

Implications for Patients and Physicians

This study highlights the importance of understanding drug interactions, especially in patients receiving multiple medications. It also suggests that careful monitoring and adjustments to medication dosages may be necessary when VPA is used in conjunction with rocuronium. This information is crucial for both patients and physicians, ensuring safe and effective treatment outcomes.

Dr. Camel's Conclusion

This research provides valuable insights into the interaction between valproic acid and rocuronium. Just as a skilled camel handler understands the nuances of their animal's behavior, physicians need to be aware of potential drug interactions to provide optimal patient care. This study emphasizes the importance of careful consideration of drug combinations and the potential need for dose adjustments.

Date :
  1. Date Completed 2012-10-23
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22767646

DOI: Digital Object Identifier

10.1093/bja/aes218

SNS
PICO Info
in preparation
Languages

English

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