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Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far?

Author: AndersenChristian R, CorrellChristoph U, MøllerBjarne K, NielsenJimmi, RøgeRasmus

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Clozapine, an antipsychotic drug for treatment-resistant schizophrenia, exhibits immunomodulatory effects. While its efficacy is well-established, further research is needed to understand its immunomodulatory mechanisms and to develop safer and more effective therapies.
Paper Details　
Original Abstract of the Article :
Clozapine remains the drug of choice for treatment resistant schizophrenia, but is associated with potentially life threatening side effects, including agranulocytosis and myocarditis. Immunological mechanisms may be involved in the development of these side effects or in the unique antipsychotic ef...See full text at original site
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引用元：
https://doi.org/10.1016/j.schres.2012.06.020

データ提供：米国国立医学図書館（NLM）

Clozapine: A Powerful Antipsychotic with a Complex Side Effect Profile

Psychiatry is a field filled with mysteries, like a vast desert with hidden oases of understanding. We're constantly seeking answers to questions about the brain and its complex workings. This research dives into the immunomodulatory effects of clozapine, a drug often used to treat schizophrenia. It utilizes a systematic review to analyze various human studies, both in vitro and in vivo, to understand how clozapine affects the immune system. The researchers aimed to connect these immunomodulatory effects to the drug's unique side effects and therapeutic benefits.

Understanding the Immune System's Role in Clozapine's Effects

The study reveals that clozapine, while effective for many, can trigger significant side effects. Up to 50% of patients might experience fever and flu-like symptoms during the first month of treatment, likely due to increased cytokine levels. The risk of serious side effects with suspected immunological mechanisms peaks within the same timeframe. This highlights the importance of monitoring patients carefully during the initial phase of treatment.

Navigating Clozapine Therapy: What to Look Out For

The researchers emphasize the need for comprehensive physical examinations and lab tests, including white blood cell counts, absolute neutrophil counts, ECGs, C-reactive protein levels, creatinine kinase levels, and troponin levels for patients experiencing fever during the first few weeks. This careful approach helps to rule out infections, agranulocytosis, myocarditis, and neuroleptic malignant syndrome. Although the study confirms clozapine's immunomodulatory actions, it also emphasizes the need for more research to fully understand the relationship between these effects and the drug's unique therapeutic efficacy in specific schizophrenia patient groups.

Dr.Camel's Conclusion

Clozapine is a powerful tool in treating schizophrenia but, like a double-edged sword, it comes with its own set of risks. Understanding its immunomodulatory effects and monitoring patients closely is crucial. Further research is necessary to fully unravel the intricate connection between the immune system and clozapine's effectiveness, paving the way for safer and more personalized treatment approaches.

Date :
  1. Date Completed 2013-01-18
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22831769

DOI: Digital Object Identifier

10.1016/j.schres.2012.06.020

SNS
PICO Info
in preparation
Languages

English

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