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Eudragit-based nanosuspension of poorly water-soluble drug: formulation and in vitro-in vivo evaluation.
Author: MishraBrahmeshwar, MishraShivani, YadavSarita Kumari
Original Abstract of the Article :
The present study was performed to investigate potential of Eudragit RLPO-based nanosuspension of glimepiride (Biopharmaceutical Classification System class II drug), for the improvement of its solubility and overall therapeutic efficacy, suitable for peroral administration. Nanoprecipitation method...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513456/
データ提供:米国国立医学図書館(NLM)
Eudragit-Based Nanosuspension: A Potential Game-Changer for Poorly Soluble Drugs?
The field of [Pharmaceutical Sciences] is constantly seeking to improve the delivery of medications, particularly those with [poor water solubility]. This study investigates the potential of [Eudragit RLPO-based nanosuspension] for enhancing the solubility and therapeutic efficacy of [glimepiride], a drug used for type 2 diabetes mellitus. The researchers employed a [nanoprecipitation method] to develop a nanosuspension formulation of glimepiride. The study demonstrates that the nanosuspension exhibits [improved in vitro drug release] characteristics and [enhanced pharmacokinetic parameters] in animal models. These findings suggest that the nanosuspension formulation could lead to [more effective and efficient treatment] for type 2 diabetes.
Eudragit-Based Nanosuspension: A Promising New Approach
This study highlights the potential benefits of [Eudragit-based nanosuspension] for improving drug delivery. The [enhanced solubility] and [improved pharmacokinetic parameters] observed in this formulation suggest that it could be a valuable approach for [formulating poorly soluble drugs] and improving their therapeutic efficacy. This research could pave the way for [more effective and convenient treatment] for various conditions.
A New Horizon for Drug Delivery
This study opens a new horizon for [drug delivery technologies]. The [Eudragit-based nanosuspension] approach offers a promising way to overcome the challenges associated with [poorly soluble drugs]. Just as a camel navigates the desert with a reliable water source, this technology could provide a way to deliver medications more effectively and efficiently.
Dr.Camel's Conclusion
This research offers a compelling case for the potential of Eudragit-based nanosuspension as a promising approach for delivering poorly soluble drugs. The study's findings suggest that this technology could lead to more effective and convenient treatment options for a wide range of conditions. It's a journey into the vast desert of drug delivery, with researchers seeking new ways to improve the lives of patients through innovative technologies.
Date :
- Date Completed 2013-05-15
- Date Revised 2022-04-10
Further Info :
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