Paper Details

  1. Home
  2. Paper Details

The immunologic injury composite with balloon injury leads to dyslipidemia: a robust rabbit model of human atherosclerosis and vulnerable plaque.

Author: LiLiangjun, LiMing, LiPeng, XuYingzhi, YangCui, ZhangGuangyin, ZhangJunping, ZhouYanan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new animal model for atherosclerosis has been developed using a combination of immunologic injury and balloon injury in cholesterol-fed white rabbits. This model could be valuable for studying the disease and testing new treatments.
Paper Details　
Original Abstract of the Article :
Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal mod...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441062/

データ提供：米国国立医学図書館（NLM）

Developing a Robust Model for Studying Atherosclerosis

Atherosclerosis, a complex disease characterized by lipid deposition, thrombus formation, and chronic inflammation, has been difficult to study effectively in animal models. This study presents a novel approach, combining immunologic injury with balloon injury in a cholesterol-fed rabbit model, to create a more accurate representation of human atherosclerosis. The authors aim to develop a robust and reliable model that mimics the key features of this debilitating disease.

A Novel Model for Studying Atherosclerosis

This study represents a significant step forward in the development of animal models for atherosclerosis research. The combined immunologic and balloon injury approach offers a more accurate and comprehensive representation of the disease process, providing valuable insights into its development and progression.

Advancing Our Understanding of Atherosclerosis

This study provides a powerful tool for studying atherosclerosis. The novel model allows researchers to explore the complex interplay of factors involved in the disease process, paving the way for a better understanding of its underlying mechanisms and the development of new therapeutic approaches.

Dr. Camel's Conclusion

This study is like a skillful camel trainer meticulously crafting a magnificent beast for a grand performance. The researchers have carefully combined different elements to create a robust model that mirrors the intricacies of atherosclerosis. This breakthrough has the potential to revolutionize our understanding of this disease and pave the way for more effective treatments.

Date :
  1. Date Completed 2013-01-16
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22988422

DOI: Digital Object Identifier

PMC3441062

Related Literature

Article Analysis
・Effective treatment of herbalism
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.